from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3288c/usfY

LFCtreatmentdescriptionclass of inhibitor

0.927

Amikacinug/mL Amikacintranslation

1.120

Cap5-10ug/mL Capreomycintranslation

1.555

Rox10-50 ug/mL Roxithromycintranslation

-0.448

SM2-5 ug/mL Streptomycintranslation

-0.029

Tet5-10 ug/mL Tetracyclinetranslation

-0.543

Rif0.2-5ug/mL Rifampicintranscription

-0.670

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.407

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

3.217

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.295

CPZ10-50 ug/mL Chlorpromazinerespiration

0.421

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.246

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.468

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.604

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.505

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.239

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.199

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.033

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.488

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.474

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.832

KCN5-20 ug/mL Potassium cyaniderespiration

-0.081

NaN30.2-2 mM Sodium aziderespiration

1.221

Nigericin50 uM Nigericinrespiration

1.153

TRC10-150 ug/mL Triclosanrespiration

1.644

TRZ10-25 ug/mL Thioridazinerespiration

0.188

Valinomycin0.5-10 uM Valinomycinrespiration

0.511

ZnSO42 mM ZnSO4respiration

-0.348

menadione6-10 ug/mL Menadionerespiration

-0.117

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.687

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.467

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.660

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.363

NRP_1Non-replicating persistence stage 1dosRassociated

-0.681

Amp0.2mg/mL AmpicillincellWall

-0.754

Cephalexin20-100 ug/mL CephalexincellWall

-0.379

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.672

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.530

EMB10-20 ug/mL EthambutolcellWall

-0.565

Eta12-40 ug/mL EthionamidecellWall

-0.344

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.534

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.430

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.970

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.301

BZA0.12 mg/mL BenzamidearomaticAmides

0.319

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.171

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.399

H2O24 mM hydrogen peroxideDNAdamaging

-0.508

Levo10 ug/mL LevofloxacinDNAdamaging

-0.804

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.402

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.450

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.726

UVUV-irradiationDNAdamaging

0.554

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.613

Antimycin12.5-50 ug/mL Antimycin A?

-0.247

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.820

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.583

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.502

PA8240.2-2 ug/mL PA-824?

0.920

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.247

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.241

Verapamil50 uM Verapamil?

-0.196

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.914

methoxatin10-20 ug/mL Methoxatin?