TB Genome Annotation Portal

Rv2150c (ftsZ)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: cell division protein ftsZ
  • REFSEQ: cell division protein FtsZ
  • PATRIC: Cell division protein FtsZ (EC 3.4.24.-)
  • TUBERCULIST: Cell division protein FtsZ
  • NCBI: Cell division protein FtsZ
  • updated information (H37Rv4):
    • gene name: ftsZ
    • function:
    • reference:
• Type: Not Target
• Start: 2408385
• End: 2409524
• Operon:


• Trans-membrane region:
  
• Role: III.C - Cell division
• GO terms:
  • GO:0051301 - cell division (Uniprot)
  • GO:0051258 - protein polymerization (Uniprot)
  • GO:0045787 - positive regulation of cell cycle (Uniprot)
  • GO:0040007 - growth (Uniprot)
  • GO:0032153 - cell division site (Uniprot)
  • GO:0007049 - cell cycle (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005737 - cytoplasm (Uniprot)
  • GO:0005525 - GTP binding (Uniprot)
  • GO:0005515 - protein binding (Uniprot)
  • GO:0003924 - GTPase activity (Uniprot)
  • GO:0000921 - septin ring assembly (Uniprot)
  • GO:0000287 - magnesium ion binding (Uniprot)
  • GO:0000166 - nucleotide binding (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure: 2q1y, 1rq7, 1rlu, 2q1x, 1rq2
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  5V68	100%	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	Crystal structure of cell division protein FtsZ from Mycobacterium tuberculosis bounded via the T9 loop
  4KWE	100%	Mycobacterium tuberculosis	GDP-bound, double-stranded, curved FtsZ protofilament structure
  2Q1Y	100%	Mycobacterium tuberculosis	Crystal Structure of cell division protein FtsZ from Mycobacterium tuberculosis in complex with GTP-gamma-S
  2Q1X	100%	Mycobacterium tuberculosis	Crystal Structure of cell division protein FtsZ from Mycobacterium tuberculosis in complex with citrate.
  1RQ7	100%	Mycobacterium tuberculosis	MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP
  1RQ2	100%	Mycobacterium tuberculosis	MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH CITRATE
  1RLU	100%	Mycobacterium tuberculosis	Mycobacterium tuberculosis FtsZ in complex with GTP-gamma-S
  5ZUE	99%	Mycobacterium tuberculosis H37Rv	GTP-bound, double-stranded, curved FtsZ protofilament structure
  4E6E	81%	Thermobifida fusca	Crystal structure of a putative cell division protein FtsZ (Tfu_1113) from Thermobifida fusca YX-ER1 at 2.22 A resolution (PSI Community Target, van Wezel G.P.)
  4U39	65%	Bacillus subtilis	Crystal Structure of FtsZ:MciZ Complex from Bacillus subtilis

• Links to additional information on ftsZ:
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -13.215 (from Jeremy Rock's lab)
  • BioCyc
  • Systems Biology

Amino Acid Sequence

MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTA
GEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITT
PGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLG
DEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGATLSIGGDDDDVDVPPFMRR

Additional Information