from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2150c/ftsZ

LFCtreatmentdescriptionclass of inhibitor

2.193

Amikacinug/mL Amikacintranslation

1.004

Cap5-10ug/mL Capreomycintranslation

0.806

Rox10-50 ug/mL Roxithromycintranslation

-0.070

SM2-5 ug/mL Streptomycintranslation

3.279

Tet5-10 ug/mL Tetracyclinetranslation

-0.413

Rif0.2-5ug/mL Rifampicintranscription

-1.128

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.352

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.470

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.518

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.452

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.825

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.184

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.019

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.843

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.058

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.492

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.375

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.107

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.533

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.218

KCN5-20 ug/mL Potassium cyaniderespiration

0.099

NaN30.2-2 mM Sodium aziderespiration

-0.254

Nigericin50 uM Nigericinrespiration

0.032

TRC10-150 ug/mL Triclosanrespiration

0.195

TRZ10-25 ug/mL Thioridazinerespiration

-1.109

Valinomycin0.5-10 uM Valinomycinrespiration

-0.084

ZnSO42 mM ZnSO4respiration

-1.306

menadione6-10 ug/mL Menadionerespiration

-0.281

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.186

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.434

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.570

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.421

NRP_1Non-replicating persistence stage 1dosRassociated

0.528

Amp0.2mg/mL AmpicillincellWall

0.919

Cephalexin20-100 ug/mL CephalexincellWall

0.226

Cerulenin0.32-5 ug/mL CerulenincellWall

0.225

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.528

EMB10-20 ug/mL EthambutolcellWall

0.693

Eta12-40 ug/mL EthionamidecellWall

1.038

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.569

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.556

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.069

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.373

BZA0.12 mg/mL BenzamidearomaticAmides

0.353

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.669

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.154

H2O24 mM hydrogen peroxideDNAdamaging

-0.997

Levo10 ug/mL LevofloxacinDNAdamaging

-0.212

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.961

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.245

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.590

UVUV-irradiationDNAdamaging

-1.156

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.929

Antimycin12.5-50 ug/mL Antimycin A?

0.535

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.991

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.708

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.156

PA8240.2-2 ug/mL PA-824?

2.042

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.227

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.395

Verapamil50 uM Verapamil?

0.395

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.374

methoxatin10-20 ug/mL Methoxatin?