TB Genome Annotation Portal

Rv2075c (-)

Amino Acid Sequence

MPRARWLQSAALMGALAVVLITAAPVAADAYQVPAPPSPTASCDVISPVAIPCVALGKFADAVAAECRRVGVPDARCVLPLAHRVTQAARDAYLQSWVHR
TARFQDALQDPVPLRETQWLGTHNSFNSLSDSFTVSHADSNQQLSLAQQLDIDVRALELDLHYLPRLEGHGAPGVTVCHGLGPKNANLGCTVEPLLATVL
PQIANWLNAPGHTEEVILLYLEDQLKNASAYESVVATLDQVLRRADGTSLIYRPNPARRATNGCVPLPLDVSREEIRASGARAVLVGSCAPGWSAAVFDW
SGVELESGSNSGYRPYPACDATYGRGVYAWRLVRYYEDSTLATALANPTRPPANPQALTPPKVPAMTDCGVNLFGFDQLLPEDGRIQASLWSWAPDEPRA
GAGACALQGADGRWVAASCGDPHPAACRDAAGRWTVTPAPVVFAGAALACTAIGADFTLPRTGNQNARLHAVAGPAGGAWVHYLLPP
(Nucleotide sequence available on KEGG)

Additional Information



ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification Condition Strain Method Reference Notes
Non-Essential Sodium Oleate H37RvMA Gumbel Subhalaxmi Nambi Probability of Essentiality: 0.000000;
2 non-insertions in a row out of 26 sites
Non-Essential Lignoceric Acid H37RvMA Gumbel Subhalaxmi Nambi Probability of Essentiality: 0.000000;
2 non-insertions in a row out of 26 sites
Non-Essential Phosphatidylcholine H37RvMA Gumbel Subhalaxmi Nambi Probability of Essentiality: 0.000000;
2 non-insertions in a row out of 26 sites
Non-Essential minimal media + 0.1% glycerol H37RvMA Gumbel Griffin et al. (2011) Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 26 sites
Non-Essential minimal media + 0.01% cholesterol H37RvMA Gumbel Griffin et al. (2011) Probability of Essentiality: 0.000000;
1 non-insertions in a row out of 26 sites
No-Data 7H10-glycerol H37RvMA TraSH Sassetti et al. (2003a)
Too-Short C57BL/6J mice (8 weeks) H37RvMA TraSH Sassetti et al. (2003b) Hybridization Ratio: -1
Non-Essential 7H09/7H10 + rich media H37RvMA MotifHMM DeJesus et al. (2017) Fully saturated (14 reps).

TnSeq Data No data currently available.
  • No TnSeq data currently available for this Target.
RNASeq Data No data currently available.
  • No RNA-Seq data currently available for this Target.
Metabolomic Profiles No data currently available.
  • No Metabolomic data currently available for this Target.
Proteomic Data No data currently available.
  • No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology
  • BioCyc

    Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

    NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

    Interactions based on ChIPSeq data

  • Interactions based on ChIPSeq data (Minch et al. 2014)

    • Binds To:

      • No bindings to other targets were found.
    • Bound By:

      • No bindings to other targets were found.

    Interactions based on TFOE data (Rustad et al. 2014)

    • Upregulates:

      • Does not upregulate other genes.
    • Upregulated by:

    • Downregulates:

      • Does not downregulate other genes.
    • Downregulated by:



    TBCAP

    Tubculosis Community Annotation Project (
    Slayden et al., 2013)

    Rv2075c (-)

    PropertyValueCreatorEvidencePMIDComment
    CitationGrowth of mycobacteria on carbon monoxide and methanol. authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim J. Bacteriol. 2003njamshidiISS16501059|12486050Reversible form added, suggestions in the literature indicate possibility of rev TCA - also Tuberculist associates EC 4.1.3.6 (rev cit lyase) with this locus. PMID: 16501059, 12486050
    TermEC:4.1.3.6 Citrate (pro-3S)-lyase. - ISSnjamshidiISS16501059|12486050Reversible form added, suggestions in the literature indicate possibility of rev TCA - also Tuberculist associates EC 4.1.3.6 (rev cit lyase) with this locus. PMID: 16501059, 12486050
    authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
    TermTBRXN:CITLr Citrate lyase (reversible) - ISSnjamshidiISS16501059|12486050Reversible form added, suggestions in the literature indicate possibility of rev TCA - also Tuberculist associates EC 4.1.3.6 (rev cit lyase) with this locus. PMID: 16501059, 12486050
    authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
    CitationAncient genes in contemporary persistent microbial pathogens. authors,V. Srinivasan,HJ. Morowitz Biol. Bull. 2006njamshidiISS16501059|12486050Reversible form added, suggestions in the literature indicate possibility of rev TCA - also Tuberculist associates EC 4.1.3.6 (rev cit lyase) with this locus. PMID: 16501059, 12486050
    TermEC:4.1.3.6 Citrate (pro-3S)-lyase. - ISSnjamshidiISS16501059|12486050Reversible form added, suggestions in the literature indicate possibility of rev TCA - also Tuberculist associates EC 4.1.3.6 (rev cit lyase) with this locus. PMID: 16501059, 12486050
    authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
    TermTBRXN:CITLr Citrate lyase (reversible) - ISSnjamshidiISS16501059|12486050Reversible form added, suggestions in the literature indicate possibility of rev TCA - also Tuberculist associates EC 4.1.3.6 (rev cit lyase) with this locus. PMID: 16501059, 12486050
    authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006

    Comments