TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2075c/-:
none

Correlation of Rv2075c/- with Rv2075c/-

Normalized LFCs for Rv2075c/-:
(description and provenance of datasets)

	Rv2075c/-	Rv2075c/-
Fe_supp_jason_reseq	-0.088	-0.088
low_pH_jason_reseq	-0.669	-0.669
NO_jason_reseq	0.389	0.389
B6_jason_reseq	0.164	0.164
MHCII_jason_reseq	0.501	0.501
Isoniazid02	0.576	0.576
Rifampicin4	0.257	0.257
Ethambutol3	-0.114	-0.114
Meropenem3	0.189	0.189
Vancomycin16	0.0	0.0
Rv2680_day32	-0.066	-0.066
H37Rv_KO_MarP	0.406	0.406
hypoxia_3wks	0.0	0.0
hypoxia_6wks	-0.121	-0.121
glycerol	0.338	0.338
cholesterol	0.247	0.247
AJ	0.188	0.188
Bibs02	-0.091	-0.091
Bibs02c	0.846	0.846
BL6	-0.335	-0.335
BL6a	0.199	0.199
BXD01	-0.463	-0.463
BXD010	-0.202	-0.202
BXD011	-0.396	-0.396
BXD03	-0.297	-0.297
BXD04	-0.853	-0.853
BXD05	-0.408	-0.408
BXD06	-0.32	-0.32
BXD07	-0.672	-0.672
BXD08	-0.413	-0.413
BXD09	-0.304	-0.304
CAST	0.322	0.322
CCcont	-0.559	-0.559
DS01	0.173	0.173
DS02	0.424	0.424
DS04	0.582	0.582
DS0c	0.542	0.542
GP01	0.122	0.122
GP02	0.834	0.834
GP0c	0.095	0.095
NOD	0.623	0.623
NZO	0.316	0.316
PWK	0.153	0.153
H37Rv_KO_CtpC	-0.565	-0.565
H37Rv_KO_CtpD	0.137	0.137
H37Rv_KO_Rv1272	0.159	0.159
H37Rv_KO_SugABC	-0.135	-0.135
H37Rv_KO_MbtN	-0.093	-0.093
Trans05	0.307	0.307
macrophage_unactivated	-0.158	-0.158
IL1	0.157	0.157
Rapamycin	-0.196	-0.196
Tcell	-0.209	-0.209
GMCSF	-0.095	-0.095
IFNab	-0.139	-0.139
IFNg	0.505	0.505
IFNg_GMCSF1	0.097	0.097
Rv1432_day32	0.296	0.296
Rv1565c_day32	-0.43	-0.43
secA2_input	0.034	0.034
delta_Rv3594	-0.101	-0.101
delta_Rv3717	0.544	0.544
delta_Rv3811	0.106	0.106
delta_Rv0954	0.726	0.726
PonA1	0.166	0.166
EccD1_KO	-0.03	-0.03
EspI_KO	0.228	0.228
PE35_KO	-0.397	-0.397
PPE68_KO	-0.374	-0.374
glycerol2	0.207	0.207
lignocerate	0.293	0.293
oleate	0.496	0.496
phosphatidylcholine	0.716	0.716
acetate	-0.047	-0.047
glucAc	-0.216	-0.216
Rv0950ko	0.335	0.335
Rv1096ko	0.29	0.29
Rv3684ko	0.295	0.295
delta_otsA_trehalose	-0.393	-0.393