TB Genome Annotation Portal

Rv1847 (-)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: hypothetical protein
  • REFSEQ: hypothetical protein
  • PATRIC: Putative esterase
  • TUBERCULIST: Conserved protein
  • NCBI: hypothetical protein
  • updated information (H37Rv4):
    • gene name: -
    • function:
    • reference:
• Type: Not Target
• Start: 2096877
• End: 2097299
• Operon:


• Trans-membrane region:
  
• Role: V - Conserved hypotheticals
• GO terms:
  • GO:0016787 - hydrolase activity (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure: 3s4k
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  3S4K	99%	Mycobacterium tuberculosis	Structure of a putative esterase Rv1847/MT1895 from Mycobacterium tuberculosis
  5HMC	51%	Streptomyces sahachiroi	Crystal structure of S. sahachiroi AziG complexed with 5-methyl naphthoic acid
  5HMB	51%	Streptomyces sahachiroi	Crystal structure of S. sahachiroi AziG
  4K4B	37%	Escherichia coli	X-ray crystal structure of E. coli YdiI complexed with undeca-2-one-CoA
  4K4A	37%	Escherichia coli	X-ray crystal structure of E. coli YdiI complexed with phenacyl-CoA
  4K49	37%	Escherichia coli	X-ray crystal structure of E. coli YdiI complexed with 2,4-dihydroxyphenacyl CoA
  1SBK	37%	Escherichia coli	X-RAY STRUCTURE OF YDII_ECOLI NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER29.
  4K4D	35%	Escherichia coli	X-ray crystal structure of E. coli YbdB complexed with 2,4-dihydroxyphenacyl-CoA
  4K4C	35%	Escherichia coli	X-ray crystal structure of E. coli YbdB complexed with phenacyl-CoA
  1VH9	35%	Escherichia coli	Crystal structure of a putative thioesterase

• Links to additional information on Rv1847:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = ? (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

VQPSPDSPAPLNVTVPFDSELGLQFTELGPDGARAQLDVRPKLLQLTGVVHGGVYCAMIESIASMAAFAWLNSHGEGGSVVGVNNNTDFVRSISSGMVYG
TAEPLHRGRRQQLWLVTITDDTDRVVARGQVRLQNLEARP

Additional Information