Rv0081 (-)

Current annotations:
- TBCAP: (community-based annotations - see table at bottom of page)
- TBDB: ArsR family transcriptional regulator
- REFSEQ: transcriptional regulatory protein
- PATRIC: Formate hydrogenlyase subunit 7
- TUBERCULIST: Probable transcriptional regulatory protein
- NCBI: Probable transcriptional regulatory protein
- updated information (H37Rv4):
  - gene name: -
  - function:
  - reference:
Type: Not Target
Start: 89575
End: 89919
Operon:

Trans-membrane region:
Role: I.J.1 - Repressors/activators
GO terms:
- GO:0006355 - regulation of transcription, DNA-templated (Uniprot)
- GO:0006351 - transcription, DNA-templated (Uniprot)
- GO:0005886 - plasma membrane (Uniprot)
- GO:0003700 - DNA binding transcription factor activity (Uniprot)
- GO:0003677 - DNA binding (Uniprot)
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB

Top 10 Homologs in PDB (as of Nov 2020):

PDB	aa ident	species	PDB title
6JMI	100%	Mycobacterium tuberculosis H37Rv	Crystal structure of M.tuberculosis Rv0081
4GGG	45%	Staphylococcus aureus subsp. aureus	Crystal structure of V66A/L68V CzrA in the Zn(II)bound state.
6CDB	42%	Staphylococcus aureus	Crystal Structure of V66L CzrA in the Zn(II)bound state
2M30	42%	Staphylococcus aureus	Solution NMR refinement of a metal ion bound protein using quantum mechanical/molecular mechanical and molecular dynamics methods
2KJC	42%	Staphylococcus aureus	Solution structure of CzrA in the Zn(II) state
2KJB	42%	Staphylococcus aureus	Solution structure of CzrA in the DNA bound state
1R1V	42%	Staphylococcus aureus	Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the Zn2-form
1R1U	42%	Staphylococcus aureus	Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form
3PQK	42%	Xylella fastidiosa	Crystal Structure of the transcriptional repressor BigR from Xylella fastidiosa
3PQJ	42%	Xylella fastidiosa	Crystal Structure of the transcriptional repressor BigR from Xylella fastidiosa

Links to additional information on Rv0081:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = 0.948 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

Amino Acid Sequence

VESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDVGLESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDR
VAVLEDLRAGGSAT

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Non-Essential	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 5 sites
Non-Essential	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 0 non-insertions in a row out of 5 sites
Non-Essential	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 0 non-insertions in a row out of 5 sites
Non-Essential	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 6 sites
Non-Essential	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 6 sites
Non-Essential	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Non-Essential	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: 0.85
Non-Essential	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- Rv0032 (bioF2) (Direct binding)
- Rv0033 (acpA) (Direct binding)
- Rv0043c (-) (Direct binding)
- Rv0045c (-) (Direct binding)
- Rv0047c (-) (Direct binding)
- Rv0057 (-) (Direct binding)
- Rv0058 (dnaB) (Direct binding)
- Rv0075 (-) (Direct binding)
- Rv0076c (-) (Direct binding)
- Rv0082 (-) (Direct binding)
- Rv0097 (-) (Direct binding)
- Rv0099 (fadD10) (Direct binding)
- Rv0113 (gmhA) (Direct binding)
- Rv0115 (hddA) (Direct binding)
- Rv0145 (-) (Direct binding)
- Rv0165c (mce1R) (Direct binding)
- Rv0166 (fadD5) (Direct binding)
- Rv0167 (yrbE1A) (Direct binding)
- Rv0178 (-) (Direct binding)
- Rv0179c (lprO) (Direct binding)
- Rv0188 (-) (Direct binding)
- Rv0196 (-) (Direct binding)
- Rv0208c (-) (Direct binding)
- Rv0214 (fadD4) (Direct binding)
- Rv0218 (-) (Direct binding)
- Rv0219 (-) (Direct binding)
- Rv0229c (-) (Direct binding)
- Rv0239 (vapB24) (Direct binding)
- Rv0240 (vapC24) (Direct binding)
- Rv0268c (-) (Direct binding)
- Rv0287 (esxG) (Direct binding)
- Rv0293c (-) (Direct binding)
- Rv0294 (tam) (Direct binding)
- Rv0305c (PPE6) (Direct binding)
- Rv0306 (-) (Direct binding)
- Rv0318c (-) (Direct binding)
- Rv0319 (pcp) (Direct binding)
- Rv0320 (-) (Direct binding)
- Rv0323c (-) (Direct binding)
- Rv0324 (-) (Direct binding)
- Rv0331 (-) (Direct binding)
- Rv0341 (iniB) (Direct binding)
- Rv0348 (-) (Direct binding)
- Rv0349 (-) (Direct binding)
- Rv0350 (dnaK) (Direct binding)
- Rv0351 (grpE) (Direct binding)
- Rv0352 (dnaJ1) (Direct binding)
- Rv0354c (PPE7) (Direct binding)
- Rv0363c (fba) (Direct binding)
- Rv0388c (PPE9) (Direct binding)
- Rv0389 (purT) (Direct binding)
- Rv0397 (-) (Direct binding)
- Rv0403c (mmpS1) (Direct binding)
- Rv0404 (fadD30) (Direct binding)
- Rv0405 (pks6) (Direct binding)
- Rv0412c (-) (Direct binding)
- Rv0413 (mutT3) (Direct binding)
- Rv0424c (-) (Direct binding)
- Rv0426c (-) (Direct binding)
- Rv0456A (mazF1) (Direct binding)
- Rv0467 (icl1) (Direct binding)
- Rv0474 (-) (Direct binding)
- Rv0475 (hbhA) (Direct binding)
- Rv0476 (-) (Direct binding)
- Rv0479c (-) (Direct binding)
- Rv0480c (-) (Direct binding)
- Rv0493c (-) (Direct binding)
- Rv0494 (-) (Direct binding)
- Rv0500A (-) (Direct binding)
- Rv0503c (cmaA2) (Direct binding)
- Rv0505c (serB1) (Direct binding)
- Rv0506 (mmpS2) (Direct binding)
- Rv0520 (-) (Direct binding)
- Rv0545c (pitA) (Direct binding)
- Rv0568 (cyp135B1) (Direct binding)
- Rv0576 (-) (Direct binding)
- Rv0578c (PE_PGRS7) (Direct binding)
- Rv0579 (-) (Direct binding)
- Rv0608 (vapB28) (Direct binding)
- Rv0653c (-) (Direct binding)
- Rv0654 (-) (Direct binding)
- Rv0657c (vapB6) (Direct binding)
- Rv0668 (rpoC) (Direct binding)
- Rv0672 (fadE8) (Direct binding)
- Rv0676c (mmpL5) (Direct binding)
- Rv0685 (tuf) (Direct binding)
- Rv0688 (-) (Direct binding)
- Rv0695 (-) (Direct binding)
- Rv0710 (rpsQ) (Direct binding)
- Rv0723 (rplO) (Direct binding)
- Rv0730 (-) (Direct binding)
- Rv0741 (-) (Direct binding)
- Rv0744c (-) (Direct binding)
- Rv0747 (PE_PGRS10) (Direct binding)
- Rv0756c (-) (Direct binding)
- Rv0757 (phoP) (Direct binding)
- Rv0790c (-) (Direct binding)
- Rv0793 (-) (Direct binding)
- Rv0820 (phoT) (Direct binding)
- Rv0821c (phoY2) (Direct binding)
- Rv0830 (-) (Direct binding)
- Rv0837c (-) (Direct binding)
- Rv0910 (-) (Direct binding)
- Rv0916c (PE7) (Direct binding)
- Rv0932c (pstS2) (Direct binding)
- Rv0933 (pstB) (Direct binding)
- Rv0934 (pstS1) (Direct binding)
- Rv0951 (sucC) (Direct binding)
- Rv0963c (-) (Direct binding)
- Rv0966c (-) (Direct binding)
- Rv0967 (csoR) (Direct binding)
- Rv0989c (grcC2) (Direct binding)
- Rv0998 (-) (Direct binding)
- Rv1013 (pks16) (Direct binding)
- Rv1033c (trcR) (Direct binding)
- Rv1039c (PPE15) (Direct binding)
- Rv1047 (-) (Direct binding)
- Rv1048c (-) (Direct binding)
- Rv1075c (-) (Direct binding)
- Rv1089A (celA2a) (Direct binding)
- Rv1113 (vapB32) (Direct binding)
- Rv1116 (-) (Direct binding)
- Rv1117 (-) (Direct binding)
- Rv1129c (-) (Direct binding)
- Rv1130 (prpD) (Direct binding)
- Rv1141c (echA11) (Direct binding)
- Rv1158c (-) (Direct binding)
- Rv1159 (pimE) (Direct binding)
- Rv1161 (narG) (Direct binding)
- Rv1180 (pks3) (Direct binding)
- Rv1190 (-) (Direct binding)
- Rv1192 (-) (Direct binding)
- Rv1198 (esxL) (Direct binding)
- Rv1204c (-) (Direct binding)
- Rv1205 (-) (Direct binding)
- Rv1206 (fadD6) (Direct binding)
- Rv1221 (sigE) (Direct binding)
- Rv1230c (-) (Direct binding)
- Rv1246c (relE) (Direct binding)
- Rv1248c (-) (Direct binding)
- Rv1256c (cyp130) (Direct binding)
- Rv1265 (-) (Direct binding)
- Rv1268c (-) (Direct binding)
- Rv1290A (-) (Direct binding)
- Rv1298 (rpmE) (Direct binding)
- Rv1302 (rfe) (Direct binding)
- Rv1305 (atpE) (Direct binding)
- Rv1308 (atpA) (Direct binding)
- Rv1313c (-) (Direct binding)
- Rv1317c (alkA) (Direct binding)
- Rv1320c (-) (Direct binding)
- Rv1321 (-) (Direct binding)
- Rv1332 (-) (Direct binding)
- Rv1339 (-) (Direct binding)
- Rv1343c (lprD) (Direct binding)
- Rv1360 (-) (Direct binding)
- Rv1361c (PPE19) (Direct binding)
- Rv1366 (-) (Direct binding)
- Rv1374c (-) (Direct binding)
- Rv1386 (PE15) (Direct binding)
- Rv1403c (-) (Direct binding)
- Rv1404 (-) (Direct binding)
- Rv1405c (-) (Direct binding)
- Rv1406 (fmt) (Direct binding)
- Rv1424c (-) (Direct binding)
- Rv1425 (-) (Direct binding)
- Rv1435c (-) (Direct binding)
- Rv1441c (PE_PGRS26) (Direct binding)
- Rv1442 (bisC) (Direct binding)
- Rv1463 (-) (Direct binding)
- Rv1471 (trxB1) (Direct binding)
- Rv1482c (-) (Direct binding)
- Rv1491c (-) (Direct binding)
- Rv1507c (-) (Direct binding)
- Rv1509 (-) (Direct binding)
- Rv1524 (-) (Direct binding)
- Rv1532c (-) (Direct binding)
- Rv1533 (-) (Direct binding)
- Rv1535 (-) (Direct binding)
- Rv1566c (-) (Direct binding)
- Rv1588c (-) (Direct binding)
- Rv1590 (-) (Direct binding)
- Rv1645c (-) (Direct binding)
- Rv1646 (PE17) (Direct binding)
- Rv1652 (argC) (Direct binding)
- Rv1665 (pks11) (Direct binding)
- Rv1672c (-) (Direct binding)
- Rv1674c (-) (Direct binding)
- Rv1687c (-) (Direct binding)
- Rv1688 (mpg) (Direct binding)
- Rv1690 (lprJ) (Direct binding)
- Rv1780 (-) (Direct binding)
- Rv1785c (cyp143) (Direct binding)
- Rv1791 (PE19) (Direct binding)
- Rv1793 (esxN) (Direct binding)
- Rv1802 (PPE30) (Direct binding)
- Rv1804c (-) (Direct binding)
- Rv1805c (-) (Direct binding)
- Rv1810 (-) (Direct binding)
- Rv1811 (mgtC) (Direct binding)
- Rv1814 (erg3) (Direct binding)
- Rv1829 (-) (Direct binding)
- Rv1863c (-) (Direct binding)
- Rv1864c (-) (Direct binding)
- Rv1875 (-) (Direct binding)
- Rv1878 (glnA3) (Direct binding)
- Rv1880c (cyp140) (Direct binding)
- Rv1902c (nanT) (Direct binding)
- Rv1920 (-) (Direct binding)
- Rv1926c (mpt63) (Direct binding)
- Rv1936 (-) (Direct binding)
- Rv1963c (mce3R) (Direct binding)
- Rv1964 (yrbE3A) (Direct binding)
- Rv1975 (-) (Direct binding)
- Rv1985c (-) (Direct binding)
- Rv1986 (-) (Direct binding)
- Rv1990c (-) (Direct binding)
- Rv1994c (cmtR) (Direct binding)
- Rv1995 (-) (Direct binding)
- Rv2009 (vapB15) (Direct binding)
- Rv2010 (vapC15) (Direct binding)
- Rv2012 (-) (Direct binding)
- Rv2034 (-) (Direct binding)
- Rv2044c (-) (Direct binding)
- Rv2055c (rpsR2) (Direct binding)
- Rv2058c (rpmB2) (Direct binding)
- Rv2059 (-) (Direct binding)
- Rv2094c (tatA) (Direct binding)
- Rv2100 (-) (Direct binding)
- Rv2107 (PE22) (Direct binding)
- Rv2108 (PPE36) (Direct binding)
- Rv2115c (mpa) (Direct binding)
- Rv2116 (lppK) (Direct binding)
- Rv2131c (cysQ) (Direct binding)
- Rv2132 (-) (Direct binding)
- Rv2137c (-) (Direct binding)
- Rv2146c (-) (Direct binding)
- Rv2148c (-) (Direct binding)
- Rv2150c (ftsZ) (Direct binding)
- Rv2161c (-) (Direct binding)
- Rv2162c (PE_PGRS38) (Direct binding)
- Rv2172c (-) (Direct binding)
- Rv2173 (idsA2) (Direct binding)
- Rv2193 (ctaE) (Direct binding)
- Rv2196 (qcrB) (Direct binding)
- Rv2202c (adoK) (Direct binding)
- Rv2203 (-) (Direct binding)
- Rv2222c (glnA2) (Direct binding)
- Rv2242 (-) (Direct binding)
- Rv2243 (fabD) (Direct binding)
- Rv2256c (-) (Direct binding)
- Rv2269c (-) (Direct binding)
- Rv2282c (-) (Direct binding)
- Rv2283 (-) (Direct binding)
- Rv2288 (-) (Direct binding)
- Rv2289 (cdh) (Direct binding)
- Rv2292c (-) (Direct binding)
- Rv2302 (-) (Direct binding)
- Rv2307A (-) (Direct binding)
- Rv2307B (-) (Direct binding)
- Rv2307c (-) (Direct binding)
- Rv2307D (-) (Direct binding)
- Rv2312 (-) (Direct binding)
- Rv2323c (-) (Direct binding)
- Rv2343c (dnaG) (Direct binding)
- Rv2346c (esxO) (Direct binding)
- Rv2347c (esxP) (Direct binding)
- Rv2348c (-) (Direct binding)
- Rv2358 (smtB) (Direct binding)
- Rv2368c (phoH1) (Direct binding)
- Rv2369c (-) (Direct binding)
- Rv2377c (mbtH) (Direct binding)
- Rv2387 (-) (Direct binding)
- Rv2391 (sirA) (Direct binding)
- Rv2412 (rpsT) (Direct binding)
- Rv2430c (PPE41) (Direct binding)
- Rv2431c (PE25) (Direct binding)
- Rv2432c (-) (Direct binding)
- Rv2452c (-) (Direct binding)
- Rv2462c (tig) (Direct binding)
- Rv2463 (lipP) (Direct binding)
- Rv2505c (fadD35) (Direct binding)
- Rv2506 (-) (Direct binding)
- Rv2516c (-) (Direct binding)
- Rv2517c (-) (Direct binding)
- Rv2525c (-) (Direct binding)
- Rv2526 (vapB17) (Direct binding)
- Rv2530A (vapB39) (Direct binding)
- Rv2535c (pepQ) (Direct binding)
- Rv2536 (-) (Direct binding)
- Rv2549c (vapC20) (Direct binding)
- Rv2550c (vapB20) (Direct binding)
- Rv2555c (alaS) (Direct binding)
- Rv2560 (-) (Direct binding)
- Rv2562 (-) (Direct binding)
- Rv2563 (-) (Direct binding)
- Rv2588c (yajC) (Direct binding)
- Rv2589 (gabT) (Direct binding)
- Rv2590 (fadD9) (Direct binding)
- Rv2594c (ruvC) (Direct binding)
- Rv2595 (vapB40) (Direct binding)
- Rv2617c (-) (Direct binding)
- Rv2633c (-) (Direct binding)
- Rv2638 (-) (Direct binding)
- Rv2643 (arsC) (Direct binding)
- Rv2645 (-) (Direct binding)
- Rv2665 (-) (Direct binding)
- Rv2666 (-) (Direct binding)
- Rv2712c (-) (Direct binding)
- Rv2713 (sthA) (Direct binding)
- Rv2720 (lexA) (Direct binding)
- Rv2722 (-) (Direct binding)
- Rv2723 (-) (Direct binding)
- Rv2724c (fadE20) (Direct binding)
- Rv2729c (-) (Direct binding)
- Rv2730 (-) (Direct binding)
- Rv2737A (-) (Direct binding)
- Rv2742c (-) (Direct binding)
- Rv2744c (35kd_ag) (Direct binding)
- Rv2779c (-) (Direct binding)
- Rv2780 (ald) (Direct binding)
- Rv2790c (ltp1) (Direct binding)
- Rv2807 (-) (Direct binding)
- Rv2808 (-) (Direct binding)
- Rv2809 (-) (Direct binding)
- Rv2827c (-) (Direct binding)
- Rv2878c (mpt53) (Direct binding)
- Rv2890c (rpsB) (Direct binding)
- Rv2939 (papA5) (Direct binding)
- Rv2947c (pks15) (Direct binding)
- Rv2948c (fadD22) (Direct binding)
- Rv2971 (-) (Direct binding)
- Rv2990c (-) (Direct binding)
- Rv2991 (-) (Direct binding)
- Rv3005c (-) (Direct binding)
- Rv3007c (-) (Direct binding)
- Rv3008 (-) (Direct binding)
- Rv3017c (esxQ) (Direct binding)
- Rv3018A (PE27A) (Direct binding)
- Rv3019c (esxR) (Direct binding)
- Rv3020c (esxS) (Direct binding)
- Rv3023c (-) (Direct binding)
- Rv3048c (nrdF2) (Direct binding)
- Rv3054c (-) (Direct binding)
- Rv3055 (-) (Direct binding)
- Rv3065 (mmr) (Direct binding)
- Rv3075c (-) (Direct binding)
- Rv3076 (-) (Direct binding)
- Rv3096 (-) (Direct binding)
- Rv3112 (moaD1) (Direct binding)
- Rv3115 (-) (Direct binding)
- Rv3124 (moaR1) (Direct binding)
- Rv3136 (PPE51) (Direct binding)
- Rv3140 (fadE23) (Direct binding)
- Rv3142c (-) (Direct binding)
- Rv3143 (-) (Direct binding)
- Rv3144c (PPE52) (Direct binding)
- Rv3146 (nuoB) (Direct binding)
- Rv3150 (nuoF) (Direct binding)
- Rv3151 (nuoG) (Direct binding)
- Rv3164c (moxR3) (Direct binding)
- Rv3179 (-) (Direct binding)
- Rv3180c (-) (Direct binding)
- Rv3181c (-) (Direct binding)
- Rv3191c (-) (Direct binding)
- Rv3219 (whiB1) (Direct binding)
- Rv3239c (-) (Direct binding)
- Rv3244c (lpqB) (Direct binding)
- Rv3248c (sahH) (Direct binding)
- Rv3249c (-) (Direct binding)
- Rv3250c (rubB) (Direct binding)
- Rv3252c (alkB) (Direct binding)
- Rv3260c (whiB2) (Direct binding)
- Rv3269 (-) (Direct binding)
- Rv3277 (-) (Direct binding)
- Rv3290c (lat) (Direct binding)
- Rv3323c (moaX) (Direct binding)
- Rv3335c (-) (Direct binding)
- Rv3348 (-) (Direct binding)
- Rv3370c (dnaE2) (Direct binding)
- Rv3371 (-) (Direct binding)
- Rv3376 (-) (Direct binding)
- Rv3382c (lytB1) (Direct binding)
- Rv3383c (idsB) (Direct binding)
- Rv3398c (idsA1) (Direct binding)
- Rv3399 (-) (Direct binding)
- Rv3407 (vapB47) (Direct binding)
- Rv3408 (vapC47) (Direct binding)
- Rv3413c (-) (Direct binding)
- Rv3415c (-) (Direct binding)
- Rv3425 (PPE57) (Direct binding)
- Rv3429 (PPE59) (Direct binding)
- Rv3441c (mrsA) (Direct binding)
- Rv3477 (PE31) (Direct binding)
- Rv3492c (-) (Direct binding)
- Rv3499c (mce4A) (Direct binding)
- Rv3500c (yrbE4B) (Direct binding)
- Rv3502c (-) (Direct binding)
- Rv3513c (fadD18) (Direct binding)
- Rv3514 (PE_PGRS57) (Direct binding)
- Rv3527 (-) (Direct binding)
- Rv3528c (-) (Direct binding)
- Rv3545c (cyp125) (Direct binding)
- Rv3546 (fadA5) (Direct binding)
- Rv3547 (ddn) (Direct binding)
- Rv3554 (fdxB) (Direct binding)
- Rv3570c (hsaA) (Direct binding)
- Rv3571 (kshB) (Direct binding)
- Rv3574 (kstR) (Direct binding)
- Rv3583c (-) (Direct binding)
- Rv3613c (-) (Direct binding)
- Rv3620c (esxW) (Direct binding)
- Rv3632 (-) (Direct binding)
- Rv3660c (-) (Direct binding)
- Rv3661 (-) (Direct binding)
- Rv3674c (nth) (Direct binding)
- Rv3675 (-) (Direct binding)
- Rv3676 (crp) (Direct binding)
- Rv3681c (whiB4) (Direct binding)
- Rv3706c (-) (Direct binding)
- Rv3728 (-) (Direct binding)
- Rv3734c (tgs2) (Direct binding)
- Rv3738c (PPE66) (Direct binding)
- Rv3743c (ctpJ) (Direct binding)
- Rv3744 (nmtR) (Direct binding)
- Rv3750c (-) (Direct binding)
- Rv3760 (-) (Direct binding)
- Rv3770c (-) (Direct binding)
- Rv3798 (-) (Direct binding)
- Rv3804c (fbpA) (Direct binding)
- Rv3811 (-) (Direct binding)
- Rv3812 (PE_PGRS62) (Direct binding)
- Rv3830c (-) (Direct binding)
- Rv3831 (-) (Direct binding)
- Rv3844 (-) (Direct binding)
- Rv3848 (-) (Direct binding)
- Rv3849 (espR) (Direct binding)
- Rv3859c (gltB) (Direct binding)
- Rv3862c (whiB6) (Direct binding)
- Rv3875 (esxA) (Direct binding)
- Rv3876 (espI) (Direct binding)
- Rv3881c (espB) (Direct binding)
- Rv3883c (mycP1) (Direct binding)
- Rv3887c (eccD2) (Direct binding)
- Rv3888c (-) (Direct binding)
- Rv3889c (espG2) (Direct binding)
- Rv3900c (-) (Direct binding)
- Rv3908 (mutT4) (Direct binding)
- Rv3919c (gid) (Direct binding)
- Rv3921c (-) (Direct binding)
- Rv3922c (-) (Direct binding)
- Rv0034 (-) (Upstream of operon)
- Rv0035 (fadD34) (Upstream of operon)
- Rv0044c (-) (Upstream of operon)
- Rv0114 (gmhB) (Upstream of operon)
- Rv0168 (yrbE1B) (Upstream of operon)
- Rv0169 (mce1A) (Upstream of operon)
- Rv0170 (mce1B) (Upstream of operon)
- Rv0171 (mce1C) (Upstream of operon)
- Rv0172 (mce1D) (Upstream of operon)
- Rv0173 (lprK) (Upstream of operon)
- Rv0174 (mce1F) (Upstream of operon)
- Rv0175 (-) (Upstream of operon)
- Rv0176 (-) (Upstream of operon)
- Rv0177 (-) (Upstream of operon)
- Rv0197 (-) (Upstream of operon)
- Rv0207c (-) (Upstream of operon)
- Rv0220 (lipC) (Upstream of operon)
- Rv0288 (esxH) (Upstream of operon)
- Rv0289 (espG3) (Upstream of operon)
- Rv0321 (dcd) (Upstream of operon)
- Rv0325 (-) (Upstream of operon)
- Rv0326 (-) (Upstream of operon)
- Rv0342 (iniA) (Upstream of operon)
- Rv0343 (iniC) (Upstream of operon)
- Rv0353 (hspR) (Upstream of operon)
- Rv0390 (-) (Upstream of operon)
- Rv0391 (metZ) (Upstream of operon)
- Rv0402c (mmpL1) (Upstream of operon)
- Rv0410c (pknG) (Upstream of operon)
- Rv0411c (glnH) (Upstream of operon)
- Rv0477 (-) (Upstream of operon)
- Rv0478 (deoC) (Upstream of operon)
- Rv0492c (-) (Upstream of operon)
- Rv0507 (mmpL2) (Upstream of operon)
- Rv0508 (-) (Upstream of operon)
- Rv0521 (-) (Upstream of operon)
- Rv0544c (-) (Upstream of operon)
- Rv0577 (TB27.3) (Upstream of operon)
- Rv0609 (vapC28) (Upstream of operon)
- Rv0609A (-) (Upstream of operon)
- Rv0655 (mkl) (Upstream of operon)
- Rv0673 (echA4) (Upstream of operon)
- Rv0674 (-) (Upstream of operon)
- Rv0675 (echA5) (Upstream of operon)
- Rv0743c (-) (Upstream of operon)
- Rv0915c (PPE14) (Upstream of operon)
- Rv0931c (pknD) (Upstream of operon)
- Rv0952 (sucD) (Upstream of operon)
- Rv0965c (-) (Upstream of operon)
- Rv1032c (trcS) (Upstream of operon)
- Rv1090 (celA2b) (Upstream of operon)
- Rv1114 (vapC32) (Upstream of operon)
- Rv1131 (prpC) (Upstream of operon)
- Rv1132 (-) (Upstream of operon)
- Rv1157c (-) (Upstream of operon)
- Rv1162 (narH) (Upstream of operon)
- Rv1193 (fadD36) (Upstream of operon)
- Rv1203c (-) (Upstream of operon)
- Rv1229c (mrp) (Upstream of operon)
- Rv1255c (-) (Upstream of operon)
- Rv1306 (atpF) (Upstream of operon)
- Rv1307 (atpH) (Upstream of operon)
- Rv1309 (atpG) (Upstream of operon)
- Rv1310 (atpD) (Upstream of operon)
- Rv1311 (atpC) (Upstream of operon)
- Rv1312 (-) (Upstream of operon)
- Rv1316c (ogt) (Upstream of operon)
- Rv1319c (-) (Upstream of operon)
- Rv1322 (-) (Upstream of operon)
- Rv1342c (-) (Upstream of operon)
- Rv1387 (PPE20) (Upstream of operon)
- Rv1407 (fmu) (Upstream of operon)
- Rv1408 (rpe) (Upstream of operon)
- Rv1409 (ribG) (Upstream of operon)
- Rv1534 (-) (Upstream of operon)
- Rv1585c (-) (Upstream of operon)
- Rv1586c (-) (Upstream of operon)
- Rv1587c (-) (Upstream of operon)
- Rv1653 (argJ) (Upstream of operon)
- Rv1654 (argB) (Upstream of operon)
- Rv1655 (argD) (Upstream of operon)
- Rv1656 (argF) (Upstream of operon)
- Rv1657 (argR) (Upstream of operon)
- Rv1658 (argG) (Upstream of operon)
- Rv1673c (-) (Upstream of operon)
- Rv1689 (tyrS) (Upstream of operon)
- Rv1691 (-) (Upstream of operon)
- Rv1692 (-) (Upstream of operon)
- Rv1693 (-) (Upstream of operon)
- Rv1694 (tlyA) (Upstream of operon)
- Rv1695 (ppnK) (Upstream of operon)
- Rv1696 (recN) (Upstream of operon)
- Rv1879 (-) (Upstream of operon)
- Rv1937 (-) (Upstream of operon)
- Rv1938 (ephB) (Upstream of operon)
- Rv1939 (-) (Upstream of operon)
- Rv1940 (ribA1) (Upstream of operon)
- Rv1941 (-) (Upstream of operon)
- Rv1965 (yrbE3B) (Upstream of operon)
- Rv1966 (mce3A) (Upstream of operon)
- Rv1967 (mce3B) (Upstream of operon)
- Rv1968 (mce3C) (Upstream of operon)
- Rv1969 (mce3D) (Upstream of operon)
- Rv1970 (lprM) (Upstream of operon)
- Rv1971 (mce3F) (Upstream of operon)
- Rv1972 (-) (Upstream of operon)
- Rv1973 (-) (Upstream of operon)
- Rv1974 (-) (Upstream of operon)
- Rv2035 (-) (Upstream of operon)
- Rv2036 (-) (Upstream of operon)
- Rv2056c (rpsN2) (Upstream of operon)
- Rv2057c (rpmG1) (Upstream of operon)
- Rv2060 (-) (Upstream of operon)
- Rv2093c (tatC) (Upstream of operon)
- Rv2117 (-) (Upstream of operon)
- Rv2147c (-) (Upstream of operon)
- Rv2149c (yfiH) (Upstream of operon)
- Rv2174 (mptA) (Upstream of operon)
- Rv2267c (-) (Upstream of operon)
- Rv2268c (cyp128) (Upstream of operon)
- Rv2284 (lipM) (Upstream of operon)
- Rv2285 (-) (Upstream of operon)
- Rv2319c (-) (Upstream of operon)
- Rv2320c (rocE) (Upstream of operon)
- Rv2321c (rocD2) (Upstream of operon)
- Rv2322c (rocD1) (Upstream of operon)
- Rv2359 (zur) (Upstream of operon)
- Rv2392 (cysH) (Upstream of operon)
- Rv2393 (che1) (Upstream of operon)
- Rv2394 (ggtB) (Upstream of operon)
- Rv2527 (vapC17) (Upstream of operon)
- Rv2532c (-) (Upstream of operon)
- Rv2533c (nusB) (Upstream of operon)
- Rv2534c (efp) (Upstream of operon)
- Rv2551c (-) (Upstream of operon)
- Rv2552c (aroE) (Upstream of operon)
- Rv2553c (-) (Upstream of operon)
- Rv2554c (-) (Upstream of operon)
- Rv2564 (glnQ) (Upstream of operon)
- Rv2592c (ruvB) (Upstream of operon)
- Rv2593c (ruvA) (Upstream of operon)
- Rv2596 (vapC40) (Upstream of operon)
- Rv2646 (-) (Upstream of operon)
- Rv2667 (clpC2) (Upstream of operon)
- Rv2731 (-) (Upstream of operon)
- Rv2743c (-) (Upstream of operon)
- Rv2778c (-) (Upstream of operon)
- Rv2826c (-) (Upstream of operon)
- Rv2877c (-) (Upstream of operon)
- Rv2888c (amiC) (Upstream of operon)
- Rv2889c (tsf) (Upstream of operon)
- Rv3056 (dinP) (Upstream of operon)
- Rv3066 (-) (Upstream of operon)
- Rv3077 (-) (Upstream of operon)
- Rv3078 (hab) (Upstream of operon)
- Rv3251c (rubA) (Upstream of operon)
- Rv3270 (ctpC) (Upstream of operon)
- Rv3288c (usfY) (Upstream of operon)
- Rv3289c (-) (Upstream of operon)
- Rv3396c (guaA) (Upstream of operon)
- Rv3397c (phyA) (Upstream of operon)
- Rv3414c (sigD) (Upstream of operon)
- Rv3478 (PPE60) (Upstream of operon)
- Rv3540c (ltp2) (Upstream of operon)
- Rv3541c (-) (Upstream of operon)
- Rv3542c (-) (Upstream of operon)
- Rv3543c (fadE29) (Upstream of operon)
- Rv3544c (fadE28) (Upstream of operon)
- Rv3566c (nat) (Upstream of operon)
- Rv3567c (hsaB) (Upstream of operon)
- Rv3568c (hsaC) (Upstream of operon)
- Rv3569c (hsaD) (Upstream of operon)
- Rv3572 (-) (Upstream of operon)
- Rv3581c (ispF) (Upstream of operon)
- Rv3582c (ispD) (Upstream of operon)
- Rv3612c (-) (Upstream of operon)
- Rv3619c (esxV) (Upstream of operon)
- Rv3673c (-) (Upstream of operon)
- Rv3733c (-) (Upstream of operon)
- Rv3845 (-) (Upstream of operon)
- Rv3858c (gltD) (Upstream of operon)
- Rv3877 (eccD1) (Upstream of operon)
- Rv3880c (espL) (Upstream of operon)
- Rv3882c (eccE1) (Upstream of operon)
- Rv3885c (eccE2) (Upstream of operon)
- Rv3886c (mycP2) (Upstream of operon)
- Rv3899c (-) (Upstream of operon)
- Rv3909 (-) (Upstream of operon)
- Rv3910 (MviN) (Upstream of operon)
- Rv3911 (sigM) (Upstream of operon)
- Rv3912 (-) (Upstream of operon)
- Rv3917c (parB) (Upstream of operon)
- Rv3918c (parA) (Upstream of operon)
Bound By:
- Rv1990c (-) (Direct binding)

Property	Value	Creator	Evidence	PMID	Comment
Citation	Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. GF. Black,BA. Thiel,MO. Ota,SK. Parida,R. Adegbola,WH. Boom,HM. Dockrell,KL. Franken,AH. Friggen,PC. Hill,MR. Klein,MK. Lalor,H. Mayanja,G. Schoolnik,K. Stanley,K. Weldingh,SH. Kaufmann,G. Walzl,TH. Ottenhoff,null. null Clin. Vaccine Immunol. 2009	harsharohiratruefriend	TAS	19553548	None
Interaction	Regulatory Rv3133c	harsharohiratruefriend	TAS		GF. Black,BA. Thiel,MO. Ota,SK. Parida,R. Adegbola,WH. Boom,HM. Dockrell,KL. Franken,AH. Friggen,PC. Hill,MR. Klein,MK. Lalor,H. Mayanja,G. Schoolnik,K. Stanley,K. Weldingh,SH. Kaufmann,G. Walzl,TH. Ottenhoff,null. null Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clin. Vaccine Immunol. 2009
Interaction	RegulatedBy Rv0182c	yamir.moreno	IEP		Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv3133c	yamir.moreno	IEP		Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. HD. Park, KM. Guinn et al. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 2003

TB Genome Annotation Portal

Rv0081 (-)

Amino Acid Sequence

Additional Information

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

Interactions based on ChIPSeq data

Interactions based on ChIPSeq data (Minch et al. 2014)

Interactions based on TFOE data (Rustad et al. 2014)

TBCAP

Comments