TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3901c/-:
none

Correlation of Rv3901c/- with Rv3901c/-

Normalized LFCs for Rv3901c/-:
(description and provenance of datasets)

	Rv3901c/-	Rv3901c/-
Fe_supp_jason_reseq	-0.543	-0.543
low_pH_jason_reseq	-0.549	-0.549
NO_jason_reseq	-0.129	-0.129
B6_jason_reseq	-0.217	-0.217
MHCII_jason_reseq	0.315	0.315
Isoniazid02	-0.095	-0.095
Rifampicin4	0.049	0.049
Ethambutol3	0.105	0.105
Meropenem3	-0.236	-0.236
Vancomycin16	0.066	0.066
Rv2680_day32	0.667	0.667
H37Rv_KO_MarP	0.145	0.145
hypoxia_3wks	-0.506	-0.506
hypoxia_6wks	-0.422	-0.422
glycerol	-0.039	-0.039
cholesterol	-0.024	-0.024
AJ	-0.059	-0.059
Bibs02	0.485	0.485
Bibs02c	-0.183	-0.183
BL6	0.468	0.468
BL6a	0.508	0.508
BXD01	0.686	0.686
BXD010	0.566	0.566
BXD011	0.507	0.507
BXD03	0.088	0.088
BXD04	0.628	0.628
BXD05	0.704	0.704
BXD06	0.494	0.494
BXD07	0.551	0.551
BXD08	0.379	0.379
BXD09	0.556	0.556
CAST	0.045	0.045
CCcont	0.641	0.641
DS01	0.065	0.065
DS02	-0.21	-0.21
DS04	0.0	0.0
DS0c	-0.196	-0.196
GP01	0.415	0.415
GP02	0.247	0.247
GP0c	-0.35	-0.35
NOD	-0.259	-0.259
NZO	0.282	0.282
PWK	-0.288	-0.288
H37Rv_KO_CtpC	0.28	0.28
H37Rv_KO_CtpD	0.964	0.964
H37Rv_KO_Rv1272	0.875	0.875
H37Rv_KO_SugABC	-0.06	-0.06
H37Rv_KO_MbtN	0.225	0.225
Trans05	0.506	0.506
macrophage_unactivated	0.363	0.363
IL1	0.128	0.128
Rapamycin	-0.531	-0.531
Tcell	0.639	0.639
GMCSF	-0.018	-0.018
IFNab	-0.378	-0.378
IFNg	0.131	0.131
IFNg_GMCSF1	0.145	0.145
Rv1432_day32	0.124	0.124
Rv1565c_day32	-0.148	-0.148
secA2_input	-0.67	-0.67
delta_Rv3594	-0.601	-0.601
delta_Rv3717	-0.578	-0.578
delta_Rv3811	-0.278	-0.278
delta_Rv0954	-0.12	-0.12
PonA1	-0.517	-0.517
EccD1_KO	-0.592	-0.592
EspI_KO	-0.639	-0.639
PE35_KO	-0.586	-0.586
PPE68_KO	-0.346	-0.346
glycerol2	0.942	0.942
lignocerate	0.654	0.654
oleate	0.33	0.33
phosphatidylcholine	0.461	0.461
acetate	-0.11	-0.11
glucAc	0.78	0.78
Rv0950ko	0.368	0.368
Rv1096ko	-0.543	-0.543
Rv3684ko	0.383	0.383
delta_otsA_trehalose	0.734	0.734