TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3893c/PE36:
none

Correlation of Rv3893c/PE36 with Rv3893c/PE36

Normalized LFCs for Rv3893c/PE36:
(description and provenance of datasets)

	Rv3893c/PE36	Rv3893c/PE36
Fe_supp_jason_reseq	-0.38	-0.38
low_pH_jason_reseq	-0.032	-0.032
NO_jason_reseq	0.058	0.058
B6_jason_reseq	0.633	0.633
MHCII_jason_reseq	0.075	0.075
Isoniazid02	-0.45	-0.45
Rifampicin4	-0.918	-0.918
Ethambutol3	0.203	0.203
Meropenem3	-0.565	-0.565
Vancomycin16	0.175	0.175
Rv2680_day32	2.339	2.339
H37Rv_KO_MarP	0.696	0.696
hypoxia_3wks	0.395	0.395
hypoxia_6wks	-0.169	-0.169
glycerol	-0.625	-0.625
cholesterol	-0.462	-0.462
AJ	-0.946	-0.946
Bibs02	-2.147	-2.147
Bibs02c	0.623	0.623
BL6	-0.71	-0.71
BL6a	-0.143	-0.143
BXD01	-1.73	-1.73
BXD010	-3.14	-3.14
BXD011	-0.764	-0.764
BXD03	-2.731	-2.731
BXD04	-2.478	-2.478
BXD05	-1.317	-1.317
BXD06	-1.646	-1.646
BXD07	-2.326	-2.326
BXD08	-1.35	-1.35
BXD09	-1.13	-1.13
CAST	0.115	0.115
CCcont	-2.44	-2.44
DS01	0.175	0.175
DS02	-0.503	-0.503
DS04	1.034	1.034
DS0c	-0.432	-0.432
GP01	0.452	0.452
GP02	-0.462	-0.462
GP0c	0.352	0.352
NOD	2.001	2.001
NZO	0.199	0.199
PWK	0.713	0.713
H37Rv_KO_CtpC	-1.795	-1.795
H37Rv_KO_CtpD	-0.512	-0.512
H37Rv_KO_Rv1272	-0.384	-0.384
H37Rv_KO_SugABC	-0.662	-0.662
H37Rv_KO_MbtN	0.42	0.42
Trans05	1.232	1.232
macrophage_unactivated	0.439	0.439
IL1	1.587	1.587
Rapamycin	0.064	0.064
Tcell	0.0	0.0
GMCSF	-1.151	-1.151
IFNab	-0.16	-0.16
IFNg	0.136	0.136
IFNg_GMCSF1	-0.031	-0.031
Rv1432_day32	-1.003	-1.003
Rv1565c_day32	0.276	0.276
secA2_input	1.872	1.872
delta_Rv3594	0.246	0.246
delta_Rv3717	1.403	1.403
delta_Rv3811	0.904	0.904
delta_Rv0954	-0.3	-0.3
PonA1	0.916	0.916
EccD1_KO	-0.513	-0.513
EspI_KO	-0.784	-0.784
PE35_KO	-1.421	-1.421
PPE68_KO	-1.414	-1.414
glycerol2	-0.217	-0.217
lignocerate	-1.145	-1.145
oleate	-0.132	-0.132
phosphatidylcholine	-1.21	-1.21
acetate	-2.977	-2.977
glucAc	-3.211	-3.211
Rv0950ko	-1.26	-1.26
Rv1096ko	-1.647	-1.647
Rv3684ko	-1.487	-1.487
delta_otsA_trehalose	-0.432	-0.432