TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3797/fadE35:
none

Correlation of Rv3797/fadE35 with Rv3797/fadE35

Normalized LFCs for Rv3797/fadE35:
(description and provenance of datasets)

	Rv3797/fadE35	Rv3797/fadE35
Fe_supp_jason_reseq	-0.289	-0.289
low_pH_jason_reseq	0.223	0.223
NO_jason_reseq	-0.176	-0.176
B6_jason_reseq	0.097	0.097
MHCII_jason_reseq	0.276	0.276
Isoniazid02	-0.237	-0.237
Rifampicin4	-0.341	-0.341
Ethambutol3	-0.041	-0.041
Meropenem3	0.139	0.139
Vancomycin16	-0.554	-0.554
Rv2680_day32	0.512	0.512
H37Rv_KO_MarP	0.145	0.145
hypoxia_3wks	0.403	0.403
hypoxia_6wks	-0.094	-0.094
glycerol	-0.756	-0.756
cholesterol	-0.392	-0.392
AJ	0.471	0.471
Bibs02	-0.354	-0.354
Bibs02c	-0.061	-0.061
BL6	-0.172	-0.172
BL6a	-0.136	-0.136
BXD01	-0.313	-0.313
BXD010	-0.516	-0.516
BXD011	-0.329	-0.329
BXD03	0.118	0.118
BXD04	-0.17	-0.17
BXD05	0.075	0.075
BXD06	-0.148	-0.148
BXD07	-0.214	-0.214
BXD08	0.11	0.11
BXD09	-0.24	-0.24
CAST	0.138	0.138
CCcont	-0.529	-0.529
DS01	0.044	0.044
DS02	0.011	0.011
DS04	-0.038	-0.038
DS0c	0.101	0.101
GP01	0.404	0.404
GP02	0.175	0.175
GP0c	0.372	0.372
NOD	0.739	0.739
NZO	0.642	0.642
PWK	0.101	0.101
H37Rv_KO_CtpC	-0.565	-0.565
H37Rv_KO_CtpD	-0.061	-0.061
H37Rv_KO_Rv1272	0.079	0.079
H37Rv_KO_SugABC	-0.573	-0.573
H37Rv_KO_MbtN	0.16	0.16
Trans05	0.33	0.33
macrophage_unactivated	-0.3	-0.3
IL1	-0.139	-0.139
Rapamycin	-0.193	-0.193
Tcell	-0.417	-0.417
GMCSF	-0.296	-0.296
IFNab	-0.363	-0.363
IFNg	-0.061	-0.061
IFNg_GMCSF1	-0.299	-0.299
Rv1432_day32	0.454	0.454
Rv1565c_day32	0.714	0.714
secA2_input	0.387	0.387
delta_Rv3594	0.138	0.138
delta_Rv3717	0.058	0.058
delta_Rv3811	0.094	0.094
delta_Rv0954	0.425	0.425
PonA1	-0.01	-0.01
EccD1_KO	-0.441	-0.441
EspI_KO	-0.337	-0.337
PE35_KO	-0.149	-0.149
PPE68_KO	-0.739	-0.739
glycerol2	-0.113	-0.113
lignocerate	0.009	0.009
oleate	0.302	0.302
phosphatidylcholine	-0.113	-0.113
acetate	-0.16	-0.16
glucAc	-0.312	-0.312
Rv0950ko	0.7	0.7
Rv1096ko	1.043	1.043
Rv3684ko	0.963	0.963
delta_otsA_trehalose	-0.491	-0.491