TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3476c/kgtP:
none

Correlation of Rv3476c/kgtP with Rv3476c/kgtP

Normalized LFCs for Rv3476c/kgtP:
(description and provenance of datasets)

	Rv3476c/kgtP	Rv3476c/kgtP
Fe_supp_jason_reseq	0.336	0.336
low_pH_jason_reseq	-0.365	-0.365
NO_jason_reseq	-0.097	-0.097
B6_jason_reseq	0.06	0.06
MHCII_jason_reseq	0.062	0.062
Isoniazid02	0.403	0.403
Rifampicin4	-0.436	-0.436
Ethambutol3	0.565	0.565
Meropenem3	-0.139	-0.139
Vancomycin16	0.106	0.106
Rv2680_day32	0.644	0.644
H37Rv_KO_MarP	0.278	0.278
hypoxia_3wks	-0.367	-0.367
hypoxia_6wks	-0.238	-0.238
glycerol	0.034	0.034
cholesterol	-0.076	-0.076
AJ	0.576	0.576
Bibs02	0.119	0.119
Bibs02c	0.126	0.126
BL6	0.594	0.594
BL6a	0.595	0.595
BXD01	0.283	0.283
BXD010	0.644	0.644
BXD011	1.009	1.009
BXD03	0.479	0.479
BXD04	0.622	0.622
BXD05	0.763	0.763
BXD06	0.473	0.473
BXD07	0.479	0.479
BXD08	0.227	0.227
BXD09	0.319	0.319
CAST	0.662	0.662
CCcont	0.449	0.449
DS01	-0.053	-0.053
DS02	-0.232	-0.232
DS04	-0.218	-0.218
DS0c	0.096	0.096
GP01	0.0	0.0
GP02	0.169	0.169
GP0c	-0.508	-0.508
NOD	0.778	0.778
NZO	0.6	0.6
PWK	0.47	0.47
H37Rv_KO_CtpC	-0.055	-0.055
H37Rv_KO_CtpD	0.942	0.942
H37Rv_KO_Rv1272	0.454	0.454
H37Rv_KO_SugABC	0.597	0.597
H37Rv_KO_MbtN	0.006	0.006
Trans05	0.236	0.236
macrophage_unactivated	0.521	0.521
IL1	0.288	0.288
Rapamycin	0.331	0.331
Tcell	0.391	0.391
GMCSF	0.346	0.346
IFNab	0.792	0.792
IFNg	0.545	0.545
IFNg_GMCSF1	0.518	0.518
Rv1432_day32	0.326	0.326
Rv1565c_day32	0.755	0.755
secA2_input	-0.778	-0.778
delta_Rv3594	-0.193	-0.193
delta_Rv3717	-0.374	-0.374
delta_Rv3811	-0.424	-0.424
delta_Rv0954	-0.459	-0.459
PonA1	0.372	0.372
EccD1_KO	-0.355	-0.355
EspI_KO	-0.279	-0.279
PE35_KO	0.268	0.268
PPE68_KO	0.029	0.029
glycerol2	0.495	0.495
lignocerate	0.353	0.353
oleate	0.594	0.594
phosphatidylcholine	0.636	0.636
acetate	-0.161	-0.161
glucAc	-0.1	-0.1
Rv0950ko	0.262	0.262
Rv1096ko	0.021	0.021
Rv3684ko	-0.072	-0.072
delta_otsA_trehalose	-0.717	-0.717