TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3391/acrA1:
none

Correlation of Rv3391/acrA1 with Rv3391/acrA1

Normalized LFCs for Rv3391/acrA1:
(description and provenance of datasets)

	Rv3391/acrA1	Rv3391/acrA1
Fe_supp_jason_reseq	0.125	0.125
low_pH_jason_reseq	-1.077	-1.077
NO_jason_reseq	-0.123	-0.123
B6_jason_reseq	-1.022	-1.022
MHCII_jason_reseq	-0.967	-0.967
Isoniazid02	-0.348	-0.348
Rifampicin4	-0.596	-0.596
Ethambutol3	0.484	0.484
Meropenem3	0.229	0.229
Vancomycin16	-0.329	-0.329
Rv2680_day32	-0.596	-0.596
H37Rv_KO_MarP	-0.154	-0.154
hypoxia_3wks	0.411	0.411
hypoxia_6wks	-0.129	-0.129
glycerol	0.0	0.0
cholesterol	0.027	0.027
AJ	-0.235	-0.235
Bibs02	-0.245	-0.245
Bibs02c	-0.191	-0.191
BL6	-0.643	-0.643
BL6a	-0.57	-0.57
BXD01	-0.443	-0.443
BXD010	-0.904	-0.904
BXD011	-0.503	-0.503
BXD03	-0.653	-0.653
BXD04	-0.561	-0.561
BXD05	-0.63	-0.63
BXD06	-0.73	-0.73
BXD07	-0.434	-0.434
BXD08	-0.507	-0.507
BXD09	-0.616	-0.616
CAST	0.0	0.0
CCcont	-0.677	-0.677
DS01	-0.679	-0.679
DS02	-0.465	-0.465
DS04	0.569	0.569
DS0c	0.181	0.181
GP01	0.346	0.346
GP02	-0.149	-0.149
GP0c	-0.051	-0.051
NOD	-0.376	-0.376
NZO	-0.019	-0.019
PWK	0.267	0.267
H37Rv_KO_CtpC	0.404	0.404
H37Rv_KO_CtpD	-0.062	-0.062
H37Rv_KO_Rv1272	0.474	0.474
H37Rv_KO_SugABC	-0.84	-0.84
H37Rv_KO_MbtN	-0.01	-0.01
Trans05	0.841	0.841
macrophage_unactivated	-0.114	-0.114
IL1	0.154	0.154
Rapamycin	0.313	0.313
Tcell	-0.117	-0.117
GMCSF	-0.143	-0.143
IFNab	0.596	0.596
IFNg	-0.294	-0.294
IFNg_GMCSF1	0.371	0.371
Rv1432_day32	-0.03	-0.03
Rv1565c_day32	-0.287	-0.287
secA2_input	-0.064	-0.064
delta_Rv3594	-0.182	-0.182
delta_Rv3717	-0.082	-0.082
delta_Rv3811	0.146	0.146
delta_Rv0954	-0.101	-0.101
PonA1	-0.45	-0.45
EccD1_KO	-0.503	-0.503
EspI_KO	-0.339	-0.339
PE35_KO	-0.446	-0.446
PPE68_KO	-0.528	-0.528
glycerol2	0.465	0.465
lignocerate	-0.244	-0.244
oleate	0.227	0.227
phosphatidylcholine	-0.392	-0.392
acetate	-0.057	-0.057
glucAc	-0.545	-0.545
Rv0950ko	0.618	0.618
Rv1096ko	0.745	0.745
Rv3684ko	0.495	0.495
delta_otsA_trehalose	0.783	0.783