TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3374/echA18.1:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation. none

Correlation of Rv3374/echA18.1 with Rv3374/echA18.1

Normalized LFCs for Rv3374/echA18.1:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv3374/echA18.1	Rv3374/echA18.1
Fe_supp_jason_reseq	0.39	0.39
low_pH_jason_reseq	-0.771	-0.771
NO_jason_reseq	-1.851	-1.851
B6_jason_reseq	-3.583	-3.583
MHCII_jason_reseq	-2.178	-2.178
Isoniazid02	-1.793	-1.793
Rifampicin4	-3.276	-3.276
Ethambutol3	-1.679	-1.679
Meropenem3	-2.008	-2.008
Vancomycin16	-2.934	-2.934
Rv2680_day32	-0.703	-0.703
H37Rv_KO_MarP	0.358	0.358
hypoxia_3wks	-1.922	-1.922
hypoxia_6wks	-1.645	-1.645
glycerol	-0.515	-0.515
cholesterol	-0.859	-0.859
AJ	0.595	0.595
Bibs02	1.731	1.731
Bibs02c	-1.05	-1.05
BL6	0.026	0.026
BL6a	0.387	0.387
BXD01	-0.463	-0.463
BXD010	-1.29	-1.29
BXD011	-0.415	-0.415
BXD03	1.861	1.861
BXD04	0.427	0.427
BXD05	0.632	0.632
BXD06	1.003	1.003
BXD07	0.95	0.95
BXD08	1.242	1.242
BXD09	0.772	0.772
CAST	0.45	0.45
CCcont	1.049	1.049
DS01	-0.026	-0.026
DS02	0.699	0.699
DS04	-0.974	-0.974
DS0c	-1.457	-1.457
GP01	-0.586	-0.586
GP02	-1.05	-1.05
GP0c	0.345	0.345
NOD	0.295	0.295
NZO	0.705	0.705
PWK	-1.668	-1.668
H37Rv_KO_CtpC	-1.883	-1.883
H37Rv_KO_CtpD	1.248	1.248
H37Rv_KO_Rv1272	-3.08	-3.08
H37Rv_KO_SugABC	2.585	2.585
H37Rv_KO_MbtN	-0.631	-0.631
Trans05	0.471	0.471
macrophage_unactivated	1.19	1.19
IL1	-0.24	-0.24
Rapamycin	2.207	2.207
Tcell	-0.264	-0.264
GMCSF	2.521	2.521
IFNab	0.079	0.079
IFNg	2.429	2.429
IFNg_GMCSF1	-1.304	-1.304
Rv1432_day32	-0.898	-0.898
Rv1565c_day32	0.907	0.907
secA2_input	1.786	1.786
delta_Rv3594	-0.295	-0.295
delta_Rv3717	0.145	0.145
delta_Rv3811	-1.825	-1.825
delta_Rv0954	-1.022	-1.022
PonA1	-0.08	-0.08
EccD1_KO	-0.056	-0.056
EspI_KO	3.73	3.73
PE35_KO	1.639	1.639
PPE68_KO	0.966	0.966
glycerol2	0.908	0.908
lignocerate	2.535	2.535
oleate	-2.052	-2.052
phosphatidylcholine	1.741	1.741
acetate	2.79	2.79
glucAc	2.542	2.542
Rv0950ko	0.769	0.769
Rv1096ko	5.145	5.145
Rv3684ko	1.66	1.66
delta_otsA_trehalose	2.201	2.201