TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3359/-:
none

Correlation of Rv3359/- with Rv3359/-

Normalized LFCs for Rv3359/-:
(description and provenance of datasets)

	Rv3359/-	Rv3359/-
Fe_supp_jason_reseq	-0.541	-0.541
low_pH_jason_reseq	-0.691	-0.691
NO_jason_reseq	-0.352	-0.352
B6_jason_reseq	-0.254	-0.254
MHCII_jason_reseq	0.023	0.023
Isoniazid02	0.754	0.754
Rifampicin4	-0.051	-0.051
Ethambutol3	0.921	0.921
Meropenem3	0.472	0.472
Vancomycin16	0.305	0.305
Rv2680_day32	0.729	0.729
H37Rv_KO_MarP	0.14	0.14
hypoxia_3wks	0.694	0.694
hypoxia_6wks	0.998	0.998
glycerol	1.083	1.083
cholesterol	0.515	0.515
AJ	-0.366	-0.366
Bibs02	0.199	0.199
Bibs02c	0.191	0.191
BL6	-0.092	-0.092
BL6a	-0.032	-0.032
BXD01	-0.448	-0.448
BXD010	-0.506	-0.506
BXD011	0.116	0.116
BXD03	0.176	0.176
BXD04	-0.118	-0.118
BXD05	0.44	0.44
BXD06	-0.353	-0.353
BXD07	0.011	0.011
BXD08	0.232	0.232
BXD09	-0.281	-0.281
CAST	0.417	0.417
CCcont	0.199	0.199
DS01	0.101	0.101
DS02	0.15	0.15
DS04	0.728	0.728
DS0c	0.658	0.658
GP01	0.317	0.317
GP02	1.08	1.08
GP0c	-0.147	-0.147
NOD	0.293	0.293
NZO	0.092	0.092
PWK	-0.337	-0.337
H37Rv_KO_CtpC	0.289	0.289
H37Rv_KO_CtpD	0.979	0.979
H37Rv_KO_Rv1272	0.011	0.011
H37Rv_KO_SugABC	0.401	0.401
H37Rv_KO_MbtN	0.294	0.294
Trans05	0.479	0.479
macrophage_unactivated	-0.136	-0.136
IL1	0.092	0.092
Rapamycin	-0.064	-0.064
Tcell	-0.085	-0.085
GMCSF	0.013	0.013
IFNab	0.139	0.139
IFNg	0.243	0.243
IFNg_GMCSF1	0.701	0.701
Rv1432_day32	0.63	0.63
Rv1565c_day32	-0.107	-0.107
secA2_input	0.164	0.164
delta_Rv3594	-0.009	-0.009
delta_Rv3717	-0.205	-0.205
delta_Rv3811	-0.865	-0.865
delta_Rv0954	-0.629	-0.629
PonA1	0.134	0.134
EccD1_KO	0.02	0.02
EspI_KO	-0.214	-0.214
PE35_KO	0.018	0.018
PPE68_KO	-0.128	-0.128
glycerol2	0.716	0.716
lignocerate	1.126	1.126
oleate	-0.275	-0.275
phosphatidylcholine	0.576	0.576
acetate	0.55	0.55
glucAc	0.988	0.988
Rv0950ko	0.642	0.642
Rv1096ko	-0.323	-0.323
Rv3684ko	0.465	0.465
delta_otsA_trehalose	0.482	0.482