TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3347c/PPE55:
none

Correlation of Rv3347c/PPE55 with Rv3347c/PPE55

Normalized LFCs for Rv3347c/PPE55:
(description and provenance of datasets)

	Rv3347c/PPE55	Rv3347c/PPE55
Fe_supp_jason_reseq	0.043	0.043
low_pH_jason_reseq	-0.691	-0.691
NO_jason_reseq	-0.223	-0.223
B6_jason_reseq	-0.245	-0.245
MHCII_jason_reseq	-0.178	-0.178
Isoniazid02	-0.405	-0.405
Rifampicin4	-0.084	-0.084
Ethambutol3	0.674	0.674
Meropenem3	0.771	0.771
Vancomycin16	-0.332	-0.332
Rv2680_day32	0.371	0.371
H37Rv_KO_MarP	0.23	0.23
hypoxia_3wks	0.024	0.024
hypoxia_6wks	0.0	0.0
glycerol	-0.143	-0.143
cholesterol	-0.014	-0.014
AJ	0.452	0.452
Bibs02	0.057	0.057
Bibs02c	0.286	0.286
BL6	0.43	0.43
BL6a	0.402	0.402
BXD01	0.443	0.443
BXD010	0.225	0.225
BXD011	0.399	0.399
BXD03	0.344	0.344
BXD04	0.603	0.603
BXD05	0.568	0.568
BXD06	0.395	0.395
BXD07	0.447	0.447
BXD08	0.309	0.309
BXD09	0.366	0.366
CAST	0.324	0.324
CCcont	0.314	0.314
DS01	0.284	0.284
DS02	0.244	0.244
DS04	0.807	0.807
DS0c	0.305	0.305
GP01	0.514	0.514
GP02	0.992	0.992
GP0c	0.493	0.493
NOD	0.421	0.421
NZO	0.5	0.5
PWK	0.574	0.574
H37Rv_KO_CtpC	0.372	0.372
H37Rv_KO_CtpD	0.909	0.909
H37Rv_KO_Rv1272	0.73	0.73
H37Rv_KO_SugABC	0.63	0.63
H37Rv_KO_MbtN	0.62	0.62
Trans05	0.71	0.71
macrophage_unactivated	0.306	0.306
IL1	0.163	0.163
Rapamycin	0.233	0.233
Tcell	-0.476	-0.476
GMCSF	0.391	0.391
IFNab	0.033	0.033
IFNg	0.259	0.259
IFNg_GMCSF1	0.544	0.544
Rv1432_day32	0.508	0.508
Rv1565c_day32	0.062	0.062
secA2_input	-0.152	-0.152
delta_Rv3594	0.008	0.008
delta_Rv3717	-0.376	-0.376
delta_Rv3811	-0.022	-0.022
delta_Rv0954	-0.28	-0.28
PonA1	-0.129	-0.129
EccD1_KO	-0.309	-0.309
EspI_KO	-0.231	-0.231
PE35_KO	-0.379	-0.379
PPE68_KO	-0.522	-0.522
glycerol2	0.366	0.366
lignocerate	0.414	0.414
oleate	0.259	0.259
phosphatidylcholine	0.522	0.522
acetate	-0.052	-0.052
glucAc	-0.139	-0.139
Rv0950ko	0.513	0.513
Rv1096ko	0.015	0.015
Rv3684ko	0.18	0.18
delta_otsA_trehalose	-0.497	-0.497