TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3343c/PPE54:
none

Correlation of Rv3343c/PPE54 with Rv3343c/PPE54

Normalized LFCs for Rv3343c/PPE54:
(description and provenance of datasets)

	Rv3343c/PPE54	Rv3343c/PPE54
Fe_supp_jason_reseq	-0.046	-0.046
low_pH_jason_reseq	-0.652	-0.652
NO_jason_reseq	-0.05	-0.05
B6_jason_reseq	-0.352	-0.352
MHCII_jason_reseq	0.036	0.036
Isoniazid02	-0.031	-0.031
Rifampicin4	0.222	0.222
Ethambutol3	0.36	0.36
Meropenem3	0.0	0.0
Vancomycin16	-0.21	-0.21
Rv2680_day32	0.194	0.194
H37Rv_KO_MarP	0.275	0.275
hypoxia_3wks	0.04	0.04
hypoxia_6wks	0.042	0.042
glycerol	0.493	0.493
cholesterol	0.241	0.241
AJ	0.492	0.492
Bibs02	0.328	0.328
Bibs02c	0.306	0.306
BL6	0.274	0.274
BL6a	0.409	0.409
BXD01	0.449	0.449
BXD010	0.39	0.39
BXD011	0.411	0.411
BXD03	0.646	0.646
BXD04	0.447	0.447
BXD05	0.378	0.378
BXD06	0.342	0.342
BXD07	0.277	0.277
BXD08	0.451	0.451
BXD09	0.317	0.317
CAST	0.369	0.369
CCcont	0.188	0.188
DS01	0.144	0.144
DS02	0.377	0.377
DS04	0.486	0.486
DS0c	0.05	0.05
GP01	0.79	0.79
GP02	0.829	0.829
GP0c	0.208	0.208
NOD	0.801	0.801
NZO	0.319	0.319
PWK	0.654	0.654
H37Rv_KO_CtpC	0.475	0.475
H37Rv_KO_CtpD	1.004	1.004
H37Rv_KO_Rv1272	0.694	0.694
H37Rv_KO_SugABC	0.741	0.741
H37Rv_KO_MbtN	1.021	1.021
Trans05	1.138	1.138
macrophage_unactivated	0.063	0.063
IL1	-0.445	-0.445
Rapamycin	-0.16	-0.16
Tcell	-0.414	-0.414
GMCSF	-0.053	-0.053
IFNab	-0.384	-0.384
IFNg	-0.027	-0.027
IFNg_GMCSF1	-0.063	-0.063
Rv1432_day32	0.106	0.106
Rv1565c_day32	-0.145	-0.145
secA2_input	-0.169	-0.169
delta_Rv3594	0.08	0.08
delta_Rv3717	-0.34	-0.34
delta_Rv3811	0.077	0.077
delta_Rv0954	-0.376	-0.376
PonA1	-0.105	-0.105
EccD1_KO	-0.444	-0.444
EspI_KO	-0.168	-0.168
PE35_KO	-0.236	-0.236
PPE68_KO	-0.189	-0.189
glycerol2	-0.045	-0.045
lignocerate	0.216	0.216
oleate	-0.03	-0.03
phosphatidylcholine	0.286	0.286
acetate	-0.276	-0.276
glucAc	-0.022	-0.022
Rv0950ko	0.214	0.214
Rv1096ko	-0.317	-0.317
Rv3684ko	-0.318	-0.318
delta_otsA_trehalose	1.285	1.285