TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3276c/purK:

update plot	correlation	link to info on gene
Rv2484c/-	(cc=0.5693)	info on Rv2484c/-
Rv0053/rpsF	(cc=0.5335)	info on Rv0053/rpsF
Rv0361/-	(cc=0.5113)	info on Rv0361/-
Rv3655c/-	(cc=0.5003)	info on Rv3655c/-
Rv3601c/panD	(cc=0.4978)	info on Rv3601c/panD
Rv2392/cysH	(cc=0.4954)	info on Rv2392/cysH
Rv2130c/mshC	(cc=0.4918)	info on Rv2130c/mshC
Rv1674c/-	(cc=0.4862)	info on Rv1674c/-
Rv3219/whiB1	(cc=0.4755)	info on Rv3219/whiB1
Rv1274/lprB	(cc=0.4585)	info on Rv1274/lprB

Correlation of Rv3276c/purK with Rv2484c/-

Normalized LFCs for Rv3276c/purK:
(description and provenance of datasets)

	Rv3276c/purK	Rv2484c/-
Fe_supp_jason_reseq	0.0	-0.219
low_pH_jason_reseq	0.0	-0.897
NO_jason_reseq	0.0	0.488
B6_jason_reseq	0.0	0.555
MHCII_jason_reseq	0.0	0.566
Isoniazid02	-0.146	1.072
Rifampicin4	-1.21	-0.46
Ethambutol3	2.247	2.559
Meropenem3	-0.701	0.424
Vancomycin16	-0.854	0.207
Rv2680_day32	-0.131	-0.358
H37Rv_KO_MarP	0.423	0.093
hypoxia_3wks	0.0	-0.044
hypoxia_6wks	0.0	0.069
glycerol	0.385	-0.298
cholesterol	0.89	0.171
AJ	0.0	0.218
Bibs02	0.0	-0.244
Bibs02c	0.209	-0.279
BL6	0.0	-0.58
BL6a	0.0	-0.689
BXD01	0.0	-0.744
BXD010	0.0	-0.494
BXD011	0.0	-0.565
BXD03	0.0	-0.374
BXD04	0.0	0.471
BXD05	0.0	-0.1
BXD06	0.0	-0.579
BXD07	0.0	0.172
BXD08	0.0	-0.063
BXD09	0.0	-0.413
CAST	0.0	0.217
CCcont	0.0	-1.236
DS01	0.0	-0.245
DS02	0.0	-0.51
DS04	0.0	0.444
DS0c	0.0	-0.116
GP01	0.0	-0.972
GP02	0.0	0.48
GP0c	0.0	-0.899
NOD	0.428	-0.044
NZO	0.0	-0.325
PWK	0.539	0.266
H37Rv_KO_CtpC	0.0	-0.966
H37Rv_KO_CtpD	0.0	-0.601
H37Rv_KO_Rv1272	0.0	-0.683
H37Rv_KO_SugABC	0.0	-0.192
H37Rv_KO_MbtN	0.0	-1.086
Trans05	0.0	-0.689
macrophage_unactivated	0.0	-1.332
IL1	0.0	-0.457
Rapamycin	0.0	-0.657
Tcell	0.0	-0.697
GMCSF	0.0	-1.077
IFNab	0.0	-0.538
IFNg	0.0	-0.056
IFNg_GMCSF1	0.0	-0.635
Rv1432_day32	0.0	0.392
Rv1565c_day32	0.0	-0.256
secA2_input	0.593	0.232
delta_Rv3594	0.211	-0.288
delta_Rv3717	0.0	-0.237
delta_Rv3811	0.391	-0.706
delta_Rv0954	0.0	0.37
PonA1	0.0	-0.171
EccD1_KO	0.454	0.878
EspI_KO	0.0	0.06
PE35_KO	1.105	1.476
PPE68_KO	1.213	1.427
glycerol2	0.0	-1.687
lignocerate	0.0	-0.616
oleate	0.0	1.212
phosphatidylcholine	0.0	-0.053
acetate	0.0	-1.257
glucAc	0.0	-2.19
Rv0950ko	0.416	0.38
Rv1096ko	1.143	1.152
Rv3684ko	2.509	1.867
delta_otsA_trehalose	0.0	-0.16