TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3239c/-:
none

Correlation of Rv3239c/- with Rv3239c/-

Normalized LFCs for Rv3239c/-:
(description and provenance of datasets)

	Rv3239c/-	Rv3239c/-
Fe_supp_jason_reseq	-0.242	-0.242
low_pH_jason_reseq	-0.656	-0.656
NO_jason_reseq	0.0	0.0
B6_jason_reseq	-0.567	-0.567
MHCII_jason_reseq	0.186	0.186
Isoniazid02	-0.32	-0.32
Rifampicin4	0.555	0.555
Ethambutol3	0.359	0.359
Meropenem3	-0.464	-0.464
Vancomycin16	-0.39	-0.39
Rv2680_day32	-0.02	-0.02
H37Rv_KO_MarP	0.008	0.008
hypoxia_3wks	-0.271	-0.271
hypoxia_6wks	-0.319	-0.319
glycerol	0.295	0.295
cholesterol	0.052	0.052
AJ	0.198	0.198
Bibs02	0.183	0.183
Bibs02c	0.011	0.011
BL6	0.481	0.481
BL6a	0.244	0.244
BXD01	0.352	0.352
BXD010	0.497	0.497
BXD011	0.0	0.0
BXD03	-0.165	-0.165
BXD04	0.225	0.225
BXD05	0.302	0.302
BXD06	0.408	0.408
BXD07	0.124	0.124
BXD08	0.195	0.195
BXD09	0.249	0.249
CAST	0.06	0.06
CCcont	0.41	0.41
DS01	0.12	0.12
DS02	0.405	0.405
DS04	0.586	0.586
DS0c	-0.328	-0.328
GP01	0.728	0.728
GP02	0.18	0.18
GP0c	0.397	0.397
NOD	0.034	0.034
NZO	0.423	0.423
PWK	0.071	0.071
H37Rv_KO_CtpC	0.426	0.426
H37Rv_KO_CtpD	0.337	0.337
H37Rv_KO_Rv1272	0.76	0.76
H37Rv_KO_SugABC	0.341	0.341
H37Rv_KO_MbtN	0.618	0.618
Trans05	0.671	0.671
macrophage_unactivated	0.035	0.035
IL1	0.614	0.614
Rapamycin	0.255	0.255
Tcell	0.199	0.199
GMCSF	-0.217	-0.217
IFNab	-0.175	-0.175
IFNg	0.016	0.016
IFNg_GMCSF1	-0.201	-0.201
Rv1432_day32	0.081	0.081
Rv1565c_day32	0.389	0.389
secA2_input	0.368	0.368
delta_Rv3594	0.382	0.382
delta_Rv3717	0.164	0.164
delta_Rv3811	0.354	0.354
delta_Rv0954	0.243	0.243
PonA1	0.112	0.112
EccD1_KO	0.368	0.368
EspI_KO	0.337	0.337
PE35_KO	-0.018	-0.018
PPE68_KO	-0.019	-0.019
glycerol2	0.345	0.345
lignocerate	0.536	0.536
oleate	0.214	0.214
phosphatidylcholine	0.452	0.452
acetate	0.071	0.071
glucAc	0.291	0.291
Rv0950ko	0.145	0.145
Rv1096ko	0.199	0.199
Rv3684ko	0.177	0.177
delta_otsA_trehalose	-0.118	-0.118