TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3063/cstA:
none

Correlation of Rv3063/cstA with Rv3063/cstA

Normalized LFCs for Rv3063/cstA:
(description and provenance of datasets)

	Rv3063/cstA	Rv3063/cstA
Fe_supp_jason_reseq	0.395	0.395
low_pH_jason_reseq	-0.202	-0.202
NO_jason_reseq	0.294	0.294
B6_jason_reseq	0.346	0.346
MHCII_jason_reseq	0.542	0.542
Isoniazid02	0.063	0.063
Rifampicin4	-0.712	-0.712
Ethambutol3	-0.045	-0.045
Meropenem3	-0.368	-0.368
Vancomycin16	-0.04	-0.04
Rv2680_day32	-0.483	-0.483
H37Rv_KO_MarP	0.22	0.22
hypoxia_3wks	0.024	0.024
hypoxia_6wks	-0.063	-0.063
glycerol	-0.039	-0.039
cholesterol	-0.157	-0.157
AJ	-0.311	-0.311
Bibs02	0.048	0.048
Bibs02c	0.086	0.086
BL6	0.119	0.119
BL6a	0.007	0.007
BXD01	-0.125	-0.125
BXD010	0.015	0.015
BXD011	-0.16	-0.16
BXD03	0.42	0.42
BXD04	-0.088	-0.088
BXD05	0.035	0.035
BXD06	-0.015	-0.015
BXD07	-0.156	-0.156
BXD08	-0.184	-0.184
BXD09	-0.044	-0.044
CAST	0.087	0.087
CCcont	-0.047	-0.047
DS01	0.036	0.036
DS02	0.41	0.41
DS04	0.295	0.295
DS0c	0.302	0.302
GP01	0.332	0.332
GP02	0.14	0.14
GP0c	-0.586	-0.586
NOD	0.076	0.076
NZO	-0.329	-0.329
PWK	0.293	0.293
H37Rv_KO_CtpC	-0.019	-0.019
H37Rv_KO_CtpD	-0.015	-0.015
H37Rv_KO_Rv1272	0.327	0.327
H37Rv_KO_SugABC	0.111	0.111
H37Rv_KO_MbtN	-0.116	-0.116
Trans05	0.388	0.388
macrophage_unactivated	-0.253	-0.253
IL1	0.018	0.018
Rapamycin	-0.445	-0.445
Tcell	-0.098	-0.098
GMCSF	-0.079	-0.079
IFNab	-0.357	-0.357
IFNg	0.171	0.171
IFNg_GMCSF1	-0.251	-0.251
Rv1432_day32	0.405	0.405
Rv1565c_day32	0.223	0.223
secA2_input	0.701	0.701
delta_Rv3594	0.506	0.506
delta_Rv3717	0.476	0.476
delta_Rv3811	-0.065	-0.065
delta_Rv0954	0.345	0.345
PonA1	0.604	0.604
EccD1_KO	0.355	0.355
EspI_KO	0.308	0.308
PE35_KO	0.481	0.481
PPE68_KO	0.022	0.022
glycerol2	0.525	0.525
lignocerate	0.686	0.686
oleate	0.458	0.458
phosphatidylcholine	0.739	0.739
acetate	0.449	0.449
glucAc	0.073	0.073
Rv0950ko	0.247	0.247
Rv1096ko	0.247	0.247
Rv3684ko	0.246	0.246
delta_otsA_trehalose	0.187	0.187