TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3027c/-:
none

Correlation of Rv3027c/- with Rv3027c/-

Normalized LFCs for Rv3027c/-:
(description and provenance of datasets)

	Rv3027c/-	Rv3027c/-
Fe_supp_jason_reseq	-0.388	-0.388
low_pH_jason_reseq	-0.586	-0.586
NO_jason_reseq	0.273	0.273
B6_jason_reseq	0.374	0.374
MHCII_jason_reseq	-0.378	-0.378
Isoniazid02	-1.008	-1.008
Rifampicin4	0.13	0.13
Ethambutol3	-0.738	-0.738
Meropenem3	-0.89	-0.89
Vancomycin16	-0.302	-0.302
Rv2680_day32	-0.617	-0.617
H37Rv_KO_MarP	0.185	0.185
hypoxia_3wks	0.024	0.024
hypoxia_6wks	-0.236	-0.236
glycerol	0.233	0.233
cholesterol	0.264	0.264
AJ	0.595	0.595
Bibs02	0.307	0.307
Bibs02c	0.352	0.352
BL6	-0.594	-0.594
BL6a	0.235	0.235
BXD01	0.308	0.308
BXD010	0.091	0.091
BXD011	-0.017	-0.017
BXD03	-0.579	-0.579
BXD04	0.166	0.166
BXD05	-0.147	-0.147
BXD06	0.062	0.062
BXD07	0.322	0.322
BXD08	0.078	0.078
BXD09	0.018	0.018
CAST	-0.05	-0.05
CCcont	-0.276	-0.276
DS01	0.515	0.515
DS02	0.588	0.588
DS04	0.382	0.382
DS0c	0.621	0.621
GP01	0.082	0.082
GP02	0.947	0.947
GP0c	-0.088	-0.088
NOD	0.882	0.882
NZO	0.221	0.221
PWK	0.286	0.286
H37Rv_KO_CtpC	-0.058	-0.058
H37Rv_KO_CtpD	0.245	0.245
H37Rv_KO_Rv1272	0.278	0.278
H37Rv_KO_SugABC	0.216	0.216
H37Rv_KO_MbtN	-0.547	-0.547
Trans05	-0.118	-0.118
macrophage_unactivated	0.177	0.177
IL1	-0.976	-0.976
Rapamycin	-0.39	-0.39
Tcell	-0.072	-0.072
GMCSF	0.29	0.29
IFNab	-0.457	-0.457
IFNg	-0.278	-0.278
IFNg_GMCSF1	-0.069	-0.069
Rv1432_day32	-0.18	-0.18
Rv1565c_day32	0.082	0.082
secA2_input	-0.327	-0.327
delta_Rv3594	0.35	0.35
delta_Rv3717	0.138	0.138
delta_Rv3811	-0.406	-0.406
delta_Rv0954	0.154	0.154
PonA1	-0.091	-0.091
EccD1_KO	0.25	0.25
EspI_KO	-0.183	-0.183
PE35_KO	-0.636	-0.636
PPE68_KO	-0.787	-0.787
glycerol2	0.762	0.762
lignocerate	0.546	0.546
oleate	0.892	0.892
phosphatidylcholine	0.798	0.798
acetate	-0.246	-0.246
glucAc	-0.198	-0.198
Rv0950ko	0.262	0.262
Rv1096ko	0.133	0.133
Rv3684ko	0.367	0.367
delta_otsA_trehalose	0.835	0.835