TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2998A/-:
none

Correlation of Rv2998A/- with Rv2998A/-

Normalized LFCs for Rv2998A/-:
(description and provenance of datasets)

	Rv2998A/-	Rv2998A/-
Fe_supp_jason_reseq	1.209	1.209
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	2.372	2.372
MHCII_jason_reseq	0.0	0.0
Isoniazid02	5.173	5.173
Rifampicin4	0.46	0.46
Ethambutol3	4.676	4.676
Meropenem3	-0.111	-0.111
Vancomycin16	-0.512	-0.512
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.454	-0.454
hypoxia_3wks	-0.55	-0.55
hypoxia_6wks	-0.288	-0.288
glycerol	-2.096	-2.096
cholesterol	0.055	0.055
AJ	0.334	0.334
Bibs02	-1.123	-1.123
Bibs02c	2.02	2.02
BL6	-1.298	-1.298
BL6a	-2.056	-2.056
BXD01	-1.352	-1.352
BXD010	-1.329	-1.329
BXD011	-1.322	-1.322
BXD03	-1.404	-1.404
BXD04	-1.284	-1.284
BXD05	-1.397	-1.397
BXD06	-1.386	-1.386
BXD07	-1.437	-1.437
BXD08	-1.381	-1.381
BXD09	-1.459	-1.459
CAST	-0.385	-0.385
CCcont	-1.55	-1.55
DS01	1.032	1.032
DS02	-1.843	-1.843
DS04	-1.332	-1.332
DS0c	-2.252	-2.252
GP01	-1.025	-1.025
GP02	-0.864	-0.864
GP0c	-1.102	-1.102
NOD	-2.332	-2.332
NZO	-0.426	-0.426
PWK	-1.347	-1.347
H37Rv_KO_CtpC	-1.686	-1.686
H37Rv_KO_CtpD	-1.315	-1.315
H37Rv_KO_Rv1272	-1.464	-1.464
H37Rv_KO_SugABC	-0.479	-0.479
H37Rv_KO_MbtN	-1.07	-1.07
Trans05	-1.356	-1.356
macrophage_unactivated	-4.353	-4.353
IL1	-4.09	-4.09
Rapamycin	-4.232	-4.232
Tcell	-4.493	-4.493
GMCSF	-3.641	-3.641
IFNab	-4.169	-4.169
IFNg	-3.685	-3.685
IFNg_GMCSF1	-4.333	-4.333
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	1.781	1.781
delta_Rv3594	-0.58	-0.58
delta_Rv3717	-0.477	-0.477
delta_Rv3811	-0.564	-0.564
delta_Rv0954	-0.49	-0.49
PonA1	-0.437	-0.437
EccD1_KO	-3.483	-3.483
EspI_KO	-3.02	-3.02
PE35_KO	-0.35	-0.35
PPE68_KO	0.182	0.182
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	1.677	1.677
Rv1096ko	0.247	0.247
Rv3684ko	-1.267	-1.267
delta_otsA_trehalose	0.0	0.0