TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2990c/-:
none

Correlation of Rv2990c/- with Rv2990c/-

Normalized LFCs for Rv2990c/-:
(description and provenance of datasets)

	Rv2990c/-	Rv2990c/-
Fe_supp_jason_reseq	-0.035	-0.035
low_pH_jason_reseq	-0.582	-0.582
NO_jason_reseq	-0.431	-0.431
B6_jason_reseq	-0.094	-0.094
MHCII_jason_reseq	0.495	0.495
Isoniazid02	0.326	0.326
Rifampicin4	-0.014	-0.014
Ethambutol3	0.057	0.057
Meropenem3	0.301	0.301
Vancomycin16	0.178	0.178
Rv2680_day32	0.422	0.422
H37Rv_KO_MarP	0.505	0.505
hypoxia_3wks	-0.024	-0.024
hypoxia_6wks	0.169	0.169
glycerol	0.146	0.146
cholesterol	-0.005	-0.005
AJ	-0.294	-0.294
Bibs02	0.0	0.0
Bibs02c	0.121	0.121
BL6	-0.019	-0.019
BL6a	-0.26	-0.26
BXD01	0.264	0.264
BXD010	-0.044	-0.044
BXD011	0.323	0.323
BXD03	-0.068	-0.068
BXD04	-0.199	-0.199
BXD05	-0.036	-0.036
BXD06	-0.163	-0.163
BXD07	-0.085	-0.085
BXD08	-0.238	-0.238
BXD09	-0.087	-0.087
CAST	0.329	0.329
CCcont	-0.176	-0.176
DS01	0.755	0.755
DS02	0.142	0.142
DS04	0.252	0.252
DS0c	0.651	0.651
GP01	0.108	0.108
GP02	0.391	0.391
GP0c	0.029	0.029
NOD	-0.182	-0.182
NZO	0.418	0.418
PWK	0.229	0.229
H37Rv_KO_CtpC	0.238	0.238
H37Rv_KO_CtpD	0.028	0.028
H37Rv_KO_Rv1272	0.515	0.515
H37Rv_KO_SugABC	-0.37	-0.37
H37Rv_KO_MbtN	0.085	0.085
Trans05	0.787	0.787
macrophage_unactivated	0.152	0.152
IL1	-0.092	-0.092
Rapamycin	-0.018	-0.018
Tcell	0.345	0.345
GMCSF	0.264	0.264
IFNab	-0.426	-0.426
IFNg	0.0	0.0
IFNg_GMCSF1	0.151	0.151
Rv1432_day32	0.199	0.199
Rv1565c_day32	-0.54	-0.54
secA2_input	0.038	0.038
delta_Rv3594	-0.647	-0.647
delta_Rv3717	-0.474	-0.474
delta_Rv3811	-0.367	-0.367
delta_Rv0954	-0.03	-0.03
PonA1	0.129	0.129
EccD1_KO	-0.358	-0.358
EspI_KO	-0.1	-0.1
PE35_KO	-0.073	-0.073
PPE68_KO	-0.211	-0.211
glycerol2	0.09	0.09
lignocerate	0.399	0.399
oleate	0.218	0.218
phosphatidylcholine	0.485	0.485
acetate	-0.168	-0.168
glucAc	0.028	0.028
Rv0950ko	0.356	0.356
Rv1096ko	-0.208	-0.208
Rv3684ko	-0.573	-0.573
delta_otsA_trehalose	-0.728	-0.728