TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2862A/vapB23:
none

Correlation of Rv2862A/vapB23 with Rv2862A/vapB23

Normalized LFCs for Rv2862A/vapB23:
(description and provenance of datasets)

	Rv2862A/vapB23	Rv2862A/vapB23
Fe_supp_jason_reseq	-3.246	-3.246
low_pH_jason_reseq	-0.606	-0.606
NO_jason_reseq	-0.47	-0.47
B6_jason_reseq	-3.327	-3.327
MHCII_jason_reseq	-3.446	-3.446
Isoniazid02	-0.061	-0.061
Rifampicin4	0.125	0.125
Ethambutol3	-0.531	-0.531
Meropenem3	-2.727	-2.727
Vancomycin16	-0.926	-0.926
Rv2680_day32	-4.159	-4.159
H37Rv_KO_MarP	1.621	1.621
hypoxia_3wks	-1.332	-1.332
hypoxia_6wks	2.74	2.74
glycerol	-0.127	-0.127
cholesterol	-1.708	-1.708
AJ	-1.168	-1.168
Bibs02	-2.339	-2.339
Bibs02c	-0.132	-0.132
BL6	-1.6	-1.6
BL6a	-0.722	-0.722
BXD01	-1.418	-1.418
BXD010	-1.394	-1.394
BXD011	0.821	0.821
BXD03	-1.73	-1.73
BXD04	0.472	0.472
BXD05	0.193	0.193
BXD06	0.118	0.118
BXD07	-1.508	-1.508
BXD08	-1.702	-1.702
BXD09	-1.657	-1.657
CAST	-2.314	-2.314
CCcont	-0.047	-0.047
DS01	1.783	1.783
DS02	4.192	4.192
DS04	-0.624	-0.624
DS0c	3.496	3.496
GP01	2.959	2.959
GP02	2.509	2.509
GP0c	3.383	3.383
NOD	-2.874	-2.874
NZO	-2.552	-2.552
PWK	-0.631	-0.631
H37Rv_KO_CtpC	2.084	2.084
H37Rv_KO_CtpD	-0.576	-0.576
H37Rv_KO_Rv1272	1.744	1.744
H37Rv_KO_SugABC	-0.55	-0.55
H37Rv_KO_MbtN	-0.956	-0.956
Trans05	-1.423	-1.423
macrophage_unactivated	0.202	0.202
IL1	0.19	0.19
Rapamycin	1.795	1.795
Tcell	-1.958	-1.958
GMCSF	-2.817	-2.817
IFNab	1.128	1.128
IFNg	-0.465	-0.465
IFNg_GMCSF1	0.487	0.487
Rv1432_day32	0.494	0.494
Rv1565c_day32	-0.924	-0.924
secA2_input	-2.691	-2.691
delta_Rv3594	-1.69	-1.69
delta_Rv3717	-1.406	-1.406
delta_Rv3811	-2.391	-2.391
delta_Rv0954	-1.492	-1.492
PonA1	-2.208	-2.208
EccD1_KO	-2.013	-2.013
EspI_KO	-0.482	-0.482
PE35_KO	2.266	2.266
PPE68_KO	2.006	2.006
glycerol2	0.0	0.0
lignocerate	0.32	0.32
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	1.294	1.294
Rv1096ko	1.119	1.119
Rv3684ko	0.632	0.632
delta_otsA_trehalose	-0.955	-0.955