TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2760c/vapB42:
none

Correlation of Rv2760c/vapB42 with Rv2760c/vapB42

Normalized LFCs for Rv2760c/vapB42:
(description and provenance of datasets)

	Rv2760c/vapB42	Rv2760c/vapB42
Fe_supp_jason_reseq	1.07	1.07
low_pH_jason_reseq	-0.216	-0.216
NO_jason_reseq	-1.305	-1.305
B6_jason_reseq	0.628	0.628
MHCII_jason_reseq	-0.629	-0.629
Isoniazid02	2.827	2.827
Rifampicin4	0.514	0.514
Ethambutol3	-0.91	-0.91
Meropenem3	-1.397	-1.397
Vancomycin16	0.0	0.0
Rv2680_day32	-3.118	-3.118
H37Rv_KO_MarP	-1.05	-1.05
hypoxia_3wks	-0.443	-0.443
hypoxia_6wks	-0.992	-0.992
glycerol	0.492	0.492
cholesterol	0.728	0.728
AJ	1.587	1.587
Bibs02	0.722	0.722
Bibs02c	0.367	0.367
BL6	1.718	1.718
BL6a	0.022	0.022
BXD01	-0.298	-0.298
BXD010	-0.177	-0.177
BXD011	0.184	0.184
BXD03	-1.201	-1.201
BXD04	-0.435	-0.435
BXD05	-0.26	-0.26
BXD06	-0.512	-0.512
BXD07	-0.367	-0.367
BXD08	0.316	0.316
BXD09	0.015	0.015
CAST	0.375	0.375
CCcont	-0.382	-0.382
DS01	1.422	1.422
DS02	1.618	1.618
DS04	-0.384	-0.384
DS0c	1.483	1.483
GP01	-1.994	-1.994
GP02	-0.506	-0.506
GP0c	-1.354	-1.354
NOD	0.428	0.428
NZO	0.022	0.022
PWK	0.117	0.117
H37Rv_KO_CtpC	-0.548	-0.548
H37Rv_KO_CtpD	-1.755	-1.755
H37Rv_KO_Rv1272	-3.075	-3.075
H37Rv_KO_SugABC	-2.537	-2.537
H37Rv_KO_MbtN	-2.48	-2.48
Trans05	-2.271	-2.271
macrophage_unactivated	0.259	0.259
IL1	-0.427	-0.427
Rapamycin	-1.022	-1.022
Tcell	-1.02	-1.02
GMCSF	-0.697	-0.697
IFNab	-0.992	-0.992
IFNg	-1.505	-1.505
IFNg_GMCSF1	-2.281	-2.281
Rv1432_day32	2.023	2.023
Rv1565c_day32	-1.26	-1.26
secA2_input	-0.875	-0.875
delta_Rv3594	-1.81	-1.81
delta_Rv3717	-0.506	-0.506
delta_Rv3811	0.378	0.378
delta_Rv0954	-1.548	-1.548
PonA1	-1.799	-1.799
EccD1_KO	2.957	2.957
EspI_KO	1.551	1.551
PE35_KO	1.765	1.765
PPE68_KO	1.968	1.968
glycerol2	-0.325	-0.325
lignocerate	-0.017	-0.017
oleate	0.15	0.15
phosphatidylcholine	0.228	0.228
acetate	-0.386	-0.386
glucAc	-0.256	-0.256
Rv0950ko	2.702	2.702
Rv1096ko	1.975	1.975
Rv3684ko	-1.785	-1.785
delta_otsA_trehalose	-1.734	-1.734