TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2614c/thrS:
none

Correlation of Rv2614c/thrS with Rv2614c/thrS

Normalized LFCs for Rv2614c/thrS:
(description and provenance of datasets)

	Rv2614c/thrS	Rv2614c/thrS
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	0.0	0.0
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	-0.202	-0.202
cholesterol	-0.145	-0.145
AJ	0.0	0.0
Bibs02	-0.183	-0.183
Bibs02c	-0.209	-0.209
BL6	-0.125	-0.125
BL6a	-0.198	-0.198
BXD01	-0.13	-0.13
BXD010	1.098	1.098
BXD011	-0.127	-0.127
BXD03	-0.135	-0.135
BXD04	-0.124	-0.124
BXD05	-0.135	-0.135
BXD06	-0.133	-0.133
BXD07	-0.138	-0.138
BXD08	-0.133	-0.133
BXD09	-0.14	-0.14
CAST	-0.23	-0.23
CCcont	-0.149	-0.149
DS01	-0.236	-0.236
DS02	-0.217	-0.217
DS04	-0.194	-0.194
DS0c	0.0	0.0
GP01	-0.099	-0.099
GP02	-0.083	-0.083
GP0c	-0.13	-0.13
NOD	-0.225	-0.225
NZO	-0.199	-0.199
PWK	0.179	0.179
H37Rv_KO_CtpC	-0.162	-0.162
H37Rv_KO_CtpD	-0.127	-0.127
H37Rv_KO_Rv1272	0.129	0.129
H37Rv_KO_SugABC	-0.099	-0.099
H37Rv_KO_MbtN	-0.103	-0.103
Trans05	0.0	0.0
macrophage_unactivated	-0.436	-0.436
IL1	-0.409	-0.409
Rapamycin	-0.424	-0.424
Tcell	0.0	0.0
GMCSF	-0.364	-0.364
IFNab	-0.417	-0.417
IFNg	-0.369	-0.369
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.0	0.0
delta_Rv3594	0.0	0.0
delta_Rv3717	0.0	0.0
delta_Rv3811	0.0	0.0
delta_Rv0954	0.0	0.0
PonA1	0.0	0.0
EccD1_KO	0.865	0.865
EspI_KO	0.0	0.0
PE35_KO	0.0	0.0
PPE68_KO	0.0	0.0
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.143	0.143
Rv0950ko	-0.416	-0.416
Rv1096ko	-0.416	-0.416
Rv3684ko	-0.452	-0.452
delta_otsA_trehalose	0.0	0.0