TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2608/PPE42:
none

Correlation of Rv2608/PPE42 with Rv2608/PPE42

Normalized LFCs for Rv2608/PPE42:
(description and provenance of datasets)

	Rv2608/PPE42	Rv2608/PPE42
Fe_supp_jason_reseq	0.253	0.253
low_pH_jason_reseq	-0.801	-0.801
NO_jason_reseq	-0.551	-0.551
B6_jason_reseq	0.073	0.073
MHCII_jason_reseq	0.331	0.331
Isoniazid02	0.067	0.067
Rifampicin4	0.336	0.336
Ethambutol3	0.653	0.653
Meropenem3	0.115	0.115
Vancomycin16	-0.207	-0.207
Rv2680_day32	-0.492	-0.492
H37Rv_KO_MarP	0.079	0.079
hypoxia_3wks	-0.459	-0.459
hypoxia_6wks	-0.572	-0.572
glycerol	-0.218	-0.218
cholesterol	-0.124	-0.124
AJ	0.492	0.492
Bibs02	-0.405	-0.405
Bibs02c	0.271	0.271
BL6	-0.277	-0.277
BL6a	0.24	0.24
BXD01	0.198	0.198
BXD010	0.534	0.534
BXD011	0.172	0.172
BXD03	0.125	0.125
BXD04	0.463	0.463
BXD05	0.722	0.722
BXD06	-0.028	-0.028
BXD07	0.035	0.035
BXD08	0.073	0.073
BXD09	0.021	0.021
CAST	-0.083	-0.083
CCcont	-0.213	-0.213
DS01	0.048	0.048
DS02	0.055	0.055
DS04	-0.417	-0.417
DS0c	-0.347	-0.347
GP01	0.159	0.159
GP02	0.557	0.557
GP0c	-0.339	-0.339
NOD	-0.373	-0.373
NZO	0.147	0.147
PWK	0.117	0.117
H37Rv_KO_CtpC	-0.042	-0.042
H37Rv_KO_CtpD	0.301	0.301
H37Rv_KO_Rv1272	0.603	0.603
H37Rv_KO_SugABC	-0.118	-0.118
H37Rv_KO_MbtN	0.148	0.148
Trans05	0.678	0.678
macrophage_unactivated	0.06	0.06
IL1	-0.653	-0.653
Rapamycin	0.058	0.058
Tcell	-0.505	-0.505
GMCSF	0.116	0.116
IFNab	-0.257	-0.257
IFNg	-0.051	-0.051
IFNg_GMCSF1	-0.421	-0.421
Rv1432_day32	0.432	0.432
Rv1565c_day32	0.084	0.084
secA2_input	-1.218	-1.218
delta_Rv3594	0.19	0.19
delta_Rv3717	0.088	0.088
delta_Rv3811	0.272	0.272
delta_Rv0954	-0.158	-0.158
PonA1	-0.125	-0.125
EccD1_KO	-0.102	-0.102
EspI_KO	0.568	0.568
PE35_KO	0.423	0.423
PPE68_KO	0.419	0.419
glycerol2	0.025	0.025
lignocerate	0.233	0.233
oleate	0.14	0.14
phosphatidylcholine	0.28	0.28
acetate	-0.143	-0.143
glucAc	-0.009	-0.009
Rv0950ko	0.268	0.268
Rv1096ko	-0.229	-0.229
Rv3684ko	-0.062	-0.062
delta_otsA_trehalose	0.78	0.78