TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2601A/vapB41:
none

Correlation of Rv2601A/vapB41 with Rv2601A/vapB41

Normalized LFCs for Rv2601A/vapB41:
(description and provenance of datasets)

	Rv2601A/vapB41	Rv2601A/vapB41
Fe_supp_jason_reseq	2.603	2.603
low_pH_jason_reseq	-1.367	-1.367
NO_jason_reseq	-1.055	-1.055
B6_jason_reseq	0.203	0.203
MHCII_jason_reseq	1.087	1.087
Isoniazid02	-0.038	-0.038
Rifampicin4	-1.313	-1.313
Ethambutol3	-0.59	-0.59
Meropenem3	-1.538	-1.538
Vancomycin16	-1.194	-1.194
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	0.226	0.226
hypoxia_3wks	-1.196	-1.196
hypoxia_6wks	-1.416	-1.416
glycerol	-1.631	-1.631
cholesterol	-0.475	-0.475
AJ	-2.086	-2.086
Bibs02	1.131	1.131
Bibs02c	0.887	0.887
BL6	-1.25	-1.25
BL6a	-1.979	-1.979
BXD01	-1.301	-1.301
BXD010	-1.279	-1.279
BXD011	-1.272	-1.272
BXD03	-1.351	-1.351
BXD04	-1.235	-1.235
BXD05	-1.344	-1.344
BXD06	-1.333	-1.333
BXD07	-1.383	-1.383
BXD08	-1.329	-1.329
BXD09	-1.404	-1.404
CAST	-0.095	-0.095
CCcont	0.223	0.223
DS01	0.092	0.092
DS02	-1.757	-1.757
DS04	-0.162	-0.162
DS0c	1.699	1.699
GP01	-0.986	-0.986
GP02	-0.831	-0.831
GP0c	-1.299	-1.299
NOD	-1.139	-1.139
NZO	1.562	1.562
PWK	-0.995	-0.995
H37Rv_KO_CtpC	-0.934	-0.934
H37Rv_KO_CtpD	-0.918	-0.918
H37Rv_KO_Rv1272	-1.409	-1.409
H37Rv_KO_SugABC	-0.57	-0.57
H37Rv_KO_MbtN	0.542	0.542
Trans05	0.779	0.779
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.857	0.857
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-3.2	-3.2
delta_Rv3594	0.428	0.428
delta_Rv3717	1.611	1.611
delta_Rv3811	3.685	3.685
delta_Rv0954	0.756	0.756
PonA1	2.45	2.45
EccD1_KO	-0.207	-0.207
EspI_KO	1.004	1.004
PE35_KO	-1.619	-1.619
PPE68_KO	-1.232	-1.232
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	3.935	3.935
Rv1096ko	3.263	3.263
Rv3684ko	6.0	6.0
delta_otsA_trehalose	-1.032	-1.032