TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2600/-:
none

Correlation of Rv2600/- with Rv2600/-

Normalized LFCs for Rv2600/-:
(description and provenance of datasets)

	Rv2600/-	Rv2600/-
Fe_supp_jason_reseq	0.213	0.213
low_pH_jason_reseq	-0.537	-0.537
NO_jason_reseq	0.013	0.013
B6_jason_reseq	0.082	0.082
MHCII_jason_reseq	0.55	0.55
Isoniazid02	0.342	0.342
Rifampicin4	-0.279	-0.279
Ethambutol3	0.019	0.019
Meropenem3	0.255	0.255
Vancomycin16	0.096	0.096
Rv2680_day32	-0.375	-0.375
H37Rv_KO_MarP	-0.151	-0.151
hypoxia_3wks	0.136	0.136
hypoxia_6wks	0.271	0.271
glycerol	-0.007	-0.007
cholesterol	0.161	0.161
AJ	0.113	0.113
Bibs02	0.673	0.673
Bibs02c	-0.499	-0.499
BL6	0.565	0.565
BL6a	-0.184	-0.184
BXD01	0.161	0.161
BXD010	0.465	0.465
BXD011	0.197	0.197
BXD03	0.678	0.678
BXD04	-0.268	-0.268
BXD05	0.605	0.605
BXD06	0.309	0.309
BXD07	0.048	0.048
BXD08	0.069	0.069
BXD09	0.129	0.129
CAST	0.158	0.158
CCcont	0.161	0.161
DS01	0.881	0.881
DS02	0.249	0.249
DS04	0.438	0.438
DS0c	0.349	0.349
GP01	0.138	0.138
GP02	-0.195	-0.195
GP0c	-0.209	-0.209
NOD	0.314	0.314
NZO	0.097	0.097
PWK	-0.486	-0.486
H37Rv_KO_CtpC	0.133	0.133
H37Rv_KO_CtpD	0.074	0.074
H37Rv_KO_Rv1272	0.728	0.728
H37Rv_KO_SugABC	1.205	1.205
H37Rv_KO_MbtN	-0.21	-0.21
Trans05	0.199	0.199
macrophage_unactivated	0.152	0.152
IL1	0.205	0.205
Rapamycin	0.055	0.055
Tcell	-0.254	-0.254
GMCSF	0.494	0.494
IFNab	0.172	0.172
IFNg	0.0	0.0
IFNg_GMCSF1	0.613	0.613
Rv1432_day32	0.763	0.763
Rv1565c_day32	0.106	0.106
secA2_input	0.601	0.601
delta_Rv3594	-0.554	-0.554
delta_Rv3717	-0.535	-0.535
delta_Rv3811	-0.458	-0.458
delta_Rv0954	0.199	0.199
PonA1	-0.461	-0.461
EccD1_KO	0.724	0.724
EspI_KO	0.867	0.867
PE35_KO	0.458	0.458
PPE68_KO	0.4	0.4
glycerol2	0.839	0.839
lignocerate	0.659	0.659
oleate	0.907	0.907
phosphatidylcholine	0.641	0.641
acetate	0.234	0.234
glucAc	0.346	0.346
Rv0950ko	0.353	0.353
Rv1096ko	0.259	0.259
Rv3684ko	0.75	0.75
delta_otsA_trehalose	1.293	1.293