TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2547/vapB19:
none

Correlation of Rv2547/vapB19 with Rv2547/vapB19

Normalized LFCs for Rv2547/vapB19:
(description and provenance of datasets)

	Rv2547/vapB19	Rv2547/vapB19
Fe_supp_jason_reseq	0.731	0.731
low_pH_jason_reseq	0.478	0.478
NO_jason_reseq	-0.231	-0.231
B6_jason_reseq	-0.347	-0.347
MHCII_jason_reseq	-2.535	-2.535
Isoniazid02	0.659	0.659
Rifampicin4	0.753	0.753
Ethambutol3	0.131	0.131
Meropenem3	3.297	3.297
Vancomycin16	0.738	0.738
Rv2680_day32	0.401	0.401
H37Rv_KO_MarP	0.763	0.763
hypoxia_3wks	-0.57	-0.57
hypoxia_6wks	-0.134	-0.134
glycerol	0.6	0.6
cholesterol	-0.319	-0.319
AJ	-0.627	-0.627
Bibs02	-2.277	-2.277
Bibs02c	-1.09	-1.09
BL6	-0.121	-0.121
BL6a	2.426	2.426
BXD01	2.313	2.313
BXD010	2.602	2.602
BXD011	2.475	2.475
BXD03	2.411	2.411
BXD04	2.98	2.98
BXD05	3.366	3.366
BXD06	1.79	1.79
BXD07	2.329	2.329
BXD08	3.113	3.113
BXD09	2.855	2.855
CAST	-2.97	-2.97
CCcont	2.842	2.842
DS01	-0.407	-0.407
DS02	2.111	2.111
DS04	1.314	1.314
DS0c	-0.55	-0.55
GP01	2.974	2.974
GP02	0.546	0.546
GP0c	1.629	1.629
NOD	-0.849	-0.849
NZO	-2.316	-2.316
PWK	0.698	0.698
H37Rv_KO_CtpC	1.603	1.603
H37Rv_KO_CtpD	1.831	1.831
H37Rv_KO_Rv1272	2.705	2.705
H37Rv_KO_SugABC	0.585	0.585
H37Rv_KO_MbtN	-0.877	-0.877
Trans05	1.495	1.495
macrophage_unactivated	0.47	0.47
IL1	0.062	0.062
Rapamycin	-0.654	-0.654
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.469	0.469
IFNg	1.072	1.072
IFNg_GMCSF1	1.392	1.392
Rv1432_day32	0.265	0.265
Rv1565c_day32	0.218	0.218
secA2_input	-0.041	-0.041
delta_Rv3594	3.491	3.491
delta_Rv3717	0.04	0.04
delta_Rv3811	1.45	1.45
delta_Rv0954	2.041	2.041
PonA1	0.383	0.383
EccD1_KO	-1.217	-1.217
EspI_KO	-1.181	-1.181
PE35_KO	-0.747	-0.747
PPE68_KO	-0.931	-0.931
glycerol2	0.696	0.696
lignocerate	0.52	0.52
oleate	1.069	1.069
phosphatidylcholine	0.574	0.574
acetate	-0.313	-0.313
glucAc	-0.46	-0.46
Rv0950ko	-1.019	-1.019
Rv1096ko	1.369	1.369
Rv3684ko	2.05	2.05
delta_otsA_trehalose	-0.716	-0.716