TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2526/vapB17:
none

Correlation of Rv2526/vapB17 with Rv2526/vapB17

Normalized LFCs for Rv2526/vapB17:
(description and provenance of datasets)

	Rv2526/vapB17	Rv2526/vapB17
Fe_supp_jason_reseq	-1.38	-1.38
low_pH_jason_reseq	0.211	0.211
NO_jason_reseq	0.914	0.914
B6_jason_reseq	-2.729	-2.729
MHCII_jason_reseq	1.599	1.599
Isoniazid02	0.0	0.0
Rifampicin4	1.048	1.048
Ethambutol3	0.231	0.231
Meropenem3	0.531	0.531
Vancomycin16	0.546	0.546
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-1.997	-1.997
hypoxia_3wks	-0.821	-0.821
hypoxia_6wks	-1.222	-1.222
glycerol	0.0	0.0
cholesterol	3.762	3.762
AJ	1.14	1.14
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	1.435	1.435
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.243	0.243
BXD03	0.258	0.258
BXD04	1.131	1.131
BXD05	0.57	0.57
BXD06	0.366	0.366
BXD07	0.486	0.486
BXD08	0.963	0.963
BXD09	0.0	0.0
CAST	4.059	4.059
CCcont	0.0	0.0
DS01	1.947	1.947
DS02	0.0	0.0
DS04	2.014	2.014
DS0c	6.0	6.0
GP01	3.111	3.111
GP02	1.227	1.227
GP0c	3.506	3.506
NOD	2.73	2.73
NZO	0.0	0.0
PWK	0.831	0.831
H37Rv_KO_CtpC	0.571	0.571
H37Rv_KO_CtpD	1.497	1.497
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	4.3	4.3
H37Rv_KO_MbtN	0.437	0.437
Trans05	0.359	0.359
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	1.524	1.524
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-3.679	-3.679
delta_Rv3594	0.0	0.0
delta_Rv3717	3.425	3.425
delta_Rv3811	3.982	3.982
delta_Rv0954	1.919	1.919
PonA1	0.0	0.0
EccD1_KO	4.7	4.7
EspI_KO	-1.081	-1.081
PE35_KO	6.0	6.0
PPE68_KO	6.0	6.0
glycerol2	-2.699	-2.699
lignocerate	-2.345	-2.345
oleate	-2.731	-2.731
phosphatidylcholine	-2.697	-2.697
acetate	-3.202	-3.202
glucAc	-1.991	-1.991
Rv0950ko	3.576	3.576
Rv1096ko	2.455	2.455
Rv3684ko	-0.894	-0.894
delta_otsA_trehalose	-2.103	-2.103