TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2423/-:
none

Correlation of Rv2423/- with Rv2423/-

Normalized LFCs for Rv2423/-:
(description and provenance of datasets)

	Rv2423/-	Rv2423/-
Fe_supp_jason_reseq	-0.103	-0.103
low_pH_jason_reseq	-0.231	-0.231
NO_jason_reseq	-0.037	-0.037
B6_jason_reseq	0.153	0.153
MHCII_jason_reseq	-0.316	-0.316
Isoniazid02	-0.358	-0.358
Rifampicin4	-0.349	-0.349
Ethambutol3	0.385	0.385
Meropenem3	0.876	0.876
Vancomycin16	-0.127	-0.127
Rv2680_day32	0.546	0.546
H37Rv_KO_MarP	0.301	0.301
hypoxia_3wks	-0.183	-0.183
hypoxia_6wks	0.0	0.0
glycerol	-0.32	-0.32
cholesterol	-0.331	-0.331
AJ	0.138	0.138
Bibs02	-0.06	-0.06
Bibs02c	0.074	0.074
BL6	-0.319	-0.319
BL6a	0.07	0.07
BXD01	0.286	0.286
BXD010	-0.042	-0.042
BXD011	0.05	0.05
BXD03	-0.272	-0.272
BXD04	0.623	0.623
BXD05	0.375	0.375
BXD06	0.159	0.159
BXD07	0.76	0.76
BXD08	0.256	0.256
BXD09	0.392	0.392
CAST	0.789	0.789
CCcont	-0.563	-0.563
DS01	-0.009	-0.009
DS02	-0.024	-0.024
DS04	-0.229	-0.229
DS0c	-0.137	-0.137
GP01	-0.152	-0.152
GP02	-0.157	-0.157
GP0c	0.381	0.381
NOD	0.208	0.208
NZO	0.871	0.871
PWK	0.757	0.757
H37Rv_KO_CtpC	0.888	0.888
H37Rv_KO_CtpD	-0.621	-0.621
H37Rv_KO_Rv1272	0.14	0.14
H37Rv_KO_SugABC	0.39	0.39
H37Rv_KO_MbtN	0.652	0.652
Trans05	0.431	0.431
macrophage_unactivated	-0.101	-0.101
IL1	0.602	0.602
Rapamycin	-0.117	-0.117
Tcell	0.368	0.368
GMCSF	0.055	0.055
IFNab	-0.082	-0.082
IFNg	0.056	0.056
IFNg_GMCSF1	0.355	0.355
Rv1432_day32	0.095	0.095
Rv1565c_day32	-0.804	-0.804
secA2_input	-1.016	-1.016
delta_Rv3594	-0.526	-0.526
delta_Rv3717	-0.196	-0.196
delta_Rv3811	0.29	0.29
delta_Rv0954	-0.006	-0.006
PonA1	-0.473	-0.473
EccD1_KO	-0.28	-0.28
EspI_KO	0.051	0.051
PE35_KO	0.102	0.102
PPE68_KO	0.448	0.448
glycerol2	0.249	0.249
lignocerate	0.341	0.341
oleate	0.313	0.313
phosphatidylcholine	0.672	0.672
acetate	-0.579	-0.579
glucAc	-0.494	-0.494
Rv0950ko	0.256	0.256
Rv1096ko	0.066	0.066
Rv3684ko	-0.088	-0.088
delta_otsA_trehalose	-0.484	-0.484