TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2395B/aprB:
none

Correlation of Rv2395B/aprB with Rv2395B/aprB

Normalized LFCs for Rv2395B/aprB:
(description and provenance of datasets)

	Rv2395B/aprB	Rv2395B/aprB
Fe_supp_jason_reseq	2.407	2.407
low_pH_jason_reseq	-1.091	-1.091
NO_jason_reseq	0.331	0.331
B6_jason_reseq	1.71	1.71
MHCII_jason_reseq	0.866	0.866
Isoniazid02	-0.387	-0.387
Rifampicin4	-1.259	-1.259
Ethambutol3	0.096	0.096
Meropenem3	3.219	3.219
Vancomycin16	-0.706	-0.706
Rv2680_day32	1.578	1.578
H37Rv_KO_MarP	0.466	0.466
hypoxia_3wks	0.694	0.694
hypoxia_6wks	0.505	0.505
glycerol	0.257	0.257
cholesterol	1.185	1.185
AJ	-0.595	-0.595
Bibs02	2.266	2.266
Bibs02c	-0.814	-0.814
BL6	-3.87	-3.87
BL6a	-1.362	-1.362
BXD01	-0.507	-0.507
BXD010	-1.302	-1.302
BXD011	-1.852	-1.852
BXD03	-1.909	-1.909
BXD04	-1.51	-1.51
BXD05	-0.098	-0.098
BXD06	-1.885	-1.885
BXD07	-0.996	-0.996
BXD08	-0.886	-0.886
BXD09	-0.638	-0.638
CAST	-0.722	-0.722
CCcont	-3.253	-3.253
DS01	0.161	0.161
DS02	1.339	1.339
DS04	1.522	1.522
DS0c	-0.665	-0.665
GP01	1.606	1.606
GP02	-0.385	-0.385
GP0c	1.474	1.474
NOD	-1.544	-1.544
NZO	1.222	1.222
PWK	-1.171	-1.171
H37Rv_KO_CtpC	-2.163	-2.163
H37Rv_KO_CtpD	-2.706	-2.706
H37Rv_KO_Rv1272	-0.926	-0.926
H37Rv_KO_SugABC	-1.893	-1.893
H37Rv_KO_MbtN	0.146	0.146
Trans05	-0.94	-0.94
macrophage_unactivated	2.92	2.92
IL1	0.0	0.0
Rapamycin	-0.924	-0.924
Tcell	1.929	1.929
GMCSF	0.882	0.882
IFNab	1.79	1.79
IFNg	2.069	2.069
IFNg_GMCSF1	1.049	1.049
Rv1432_day32	0.314	0.314
Rv1565c_day32	0.521	0.521
secA2_input	-4.904	-4.904
delta_Rv3594	-2.109	-2.109
delta_Rv3717	-0.583	-0.583
delta_Rv3811	-1.807	-1.807
delta_Rv0954	-2.801	-2.801
PonA1	-1.764	-1.764
EccD1_KO	2.434	2.434
EspI_KO	3.479	3.479
PE35_KO	2.281	2.281
PPE68_KO	2.198	2.198
glycerol2	0.056	0.056
lignocerate	-0.995	-0.995
oleate	0.866	0.866
phosphatidylcholine	0.227	0.227
acetate	-0.715	-0.715
glucAc	-4.812	-4.812
Rv0950ko	1.978	1.978
Rv1096ko	2.054	2.054
Rv3684ko	1.248	1.248
delta_otsA_trehalose	0.818	0.818