TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2348c/-:
none

Correlation of Rv2348c/- with Rv2348c/-

Normalized LFCs for Rv2348c/-:
(description and provenance of datasets)

	Rv2348c/-	Rv2348c/-
Fe_supp_jason_reseq	-0.938	-0.938
low_pH_jason_reseq	-2.516	-2.516
NO_jason_reseq	1.709	1.709
B6_jason_reseq	-0.357	-0.357
MHCII_jason_reseq	0.153	0.153
Isoniazid02	-0.196	-0.196
Rifampicin4	0.149	0.149
Ethambutol3	-0.097	-0.097
Meropenem3	0.91	0.91
Vancomycin16	-0.435	-0.435
Rv2680_day32	-1.884	-1.884
H37Rv_KO_MarP	0.151	0.151
hypoxia_3wks	0.865	0.865
hypoxia_6wks	0.142	0.142
glycerol	-3.781	-3.781
cholesterol	-0.907	-0.907
AJ	-0.376	-0.376
Bibs02	0.203	0.203
Bibs02c	-1.523	-1.523
BL6	-1.02	-1.02
BL6a	-0.911	-0.911
BXD01	0.669	0.669
BXD010	-1.011	-1.011
BXD011	-0.133	-0.133
BXD03	-2.469	-2.469
BXD04	0.89	0.89
BXD05	0.282	0.282
BXD06	-0.223	-0.223
BXD07	-0.599	-0.599
BXD08	-1.114	-1.114
BXD09	-0.098	-0.098
CAST	-0.093	-0.093
CCcont	-0.846	-0.846
DS01	0.609	0.609
DS02	-3.017	-3.017
DS04	-0.805	-0.805
DS0c	-2.75	-2.75
GP01	-0.289	-0.289
GP02	-1.192	-1.192
GP0c	-0.367	-0.367
NOD	1.712	1.712
NZO	-0.696	-0.696
PWK	-0.075	-0.075
H37Rv_KO_CtpC	-0.839	-0.839
H37Rv_KO_CtpD	0.122	0.122
H37Rv_KO_Rv1272	-0.366	-0.366
H37Rv_KO_SugABC	-0.22	-0.22
H37Rv_KO_MbtN	0.741	0.741
Trans05	1.054	1.054
macrophage_unactivated	-2.25	-2.25
IL1	-0.997	-0.997
Rapamycin	-1.289	-1.289
Tcell	-0.192	-0.192
GMCSF	-0.359	-0.359
IFNab	-2.319	-2.319
IFNg	-2.101	-2.101
IFNg_GMCSF1	-1.458	-1.458
Rv1432_day32	0.381	0.381
Rv1565c_day32	0.224	0.224
secA2_input	0.412	0.412
delta_Rv3594	-1.069	-1.069
delta_Rv3717	-0.668	-0.668
delta_Rv3811	-1.087	-1.087
delta_Rv0954	0.649	0.649
PonA1	0.351	0.351
EccD1_KO	0.618	0.618
EspI_KO	-0.228	-0.228
PE35_KO	0.035	0.035
PPE68_KO	-0.086	-0.086
glycerol2	0.408	0.408
lignocerate	-0.839	-0.839
oleate	-0.815	-0.815
phosphatidylcholine	-0.465	-0.465
acetate	-0.268	-0.268
glucAc	0.412	0.412
Rv0950ko	0.042	0.042
Rv1096ko	-0.323	-0.323
Rv3684ko	-0.21	-0.21
delta_otsA_trehalose	-0.041	-0.041