TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2304c/-:
none

Correlation of Rv2304c/- with Rv2304c/-

Normalized LFCs for Rv2304c/-:
(description and provenance of datasets)

	Rv2304c/-	Rv2304c/-
Fe_supp_jason_reseq	-3.385	-3.385
low_pH_jason_reseq	-2.797	-2.797
NO_jason_reseq	-2.281	-2.281
B6_jason_reseq	-1.646	-1.646
MHCII_jason_reseq	-3.69	-3.69
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.366	0.366
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	3.392	3.392
hypoxia_3wks	-0.989	-0.989
hypoxia_6wks	-2.088	-2.088
glycerol	1.748	1.748
cholesterol	-0.476	-0.476
AJ	-0.571	-0.571
Bibs02	-2.118	-2.118
Bibs02c	0.688	0.688
BL6	-3.01	-3.01
BL6a	0.271	0.271
BXD01	-3.134	-3.134
BXD010	-3.082	-3.082
BXD011	-0.949	-0.949
BXD03	-3.254	-3.254
BXD04	-2.976	-2.976
BXD05	-2.766	-2.766
BXD06	-3.212	-3.212
BXD07	-3.332	-3.332
BXD08	-3.201	-3.201
BXD09	-3.382	-3.382
CAST	0.23	0.23
CCcont	-3.444	-3.444
DS01	-0.205	-0.205
DS02	-0.564	-0.564
DS04	0.578	0.578
DS0c	2.022	2.022
GP01	-1.611	-1.611
GP02	-2.002	-2.002
GP0c	-3.129	-3.129
NOD	1.58	1.58
NZO	2.358	2.358
PWK	1.716	1.716
H37Rv_KO_CtpC	-1.046	-1.046
H37Rv_KO_CtpD	-2.066	-2.066
H37Rv_KO_Rv1272	1.778	1.778
H37Rv_KO_SugABC	-1.719	-1.719
H37Rv_KO_MbtN	1.721	1.721
Trans05	0.203	0.203
macrophage_unactivated	-0.436	-0.436
IL1	0.0	0.0
Rapamycin	-0.424	-0.424
Tcell	-0.45	-0.45
GMCSF	-0.364	-0.364
IFNab	-0.417	-0.417
IFNg	-0.369	-0.369
IFNg_GMCSF1	-0.434	-0.434
Rv1432_day32	0.18	0.18
Rv1565c_day32	0.0	0.0
secA2_input	5.233	5.233
delta_Rv3594	-0.846	-0.846
delta_Rv3717	-3.094	-3.094
delta_Rv3811	-4.048	-4.048
delta_Rv0954	-3.517	-3.517
PonA1	2.954	2.954
EccD1_KO	-1.365	-1.365
EspI_KO	-2.073	-2.073
PE35_KO	-3.684	-3.684
PPE68_KO	-4.79	-4.79
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	1.87	1.87
Rv1096ko	0.0	0.0
Rv3684ko	0.937	0.937
delta_otsA_trehalose	3.537	3.537