TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2294/-:
none

Correlation of Rv2294/- with Rv2294/-

Normalized LFCs for Rv2294/-:
(description and provenance of datasets)

	Rv2294/-	Rv2294/-
Fe_supp_jason_reseq	-0.379	-0.379
low_pH_jason_reseq	-0.353	-0.353
NO_jason_reseq	-0.302	-0.302
B6_jason_reseq	-0.418	-0.418
MHCII_jason_reseq	0.048	0.048
Isoniazid02	0.108	0.108
Rifampicin4	-0.116	-0.116
Ethambutol3	0.866	0.866
Meropenem3	-0.892	-0.892
Vancomycin16	-0.501	-0.501
Rv2680_day32	0.557	0.557
H37Rv_KO_MarP	-0.347	-0.347
hypoxia_3wks	-0.128	-0.128
hypoxia_6wks	0.512	0.512
glycerol	-0.335	-0.335
cholesterol	-0.248	-0.248
AJ	0.375	0.375
Bibs02	0.295	0.295
Bibs02c	0.283	0.283
BL6	0.587	0.587
BL6a	0.277	0.277
BXD01	-0.346	-0.346
BXD010	0.188	0.188
BXD011	0.0	0.0
BXD03	0.051	0.051
BXD04	0.341	0.341
BXD05	0.276	0.276
BXD06	-0.006	-0.006
BXD07	-0.072	-0.072
BXD08	0.512	0.512
BXD09	0.07	0.07
CAST	0.03	0.03
CCcont	0.29	0.29
DS01	0.424	0.424
DS02	0.414	0.414
DS04	0.025	0.025
DS0c	0.421	0.421
GP01	0.301	0.301
GP02	-0.036	-0.036
GP0c	0.262	0.262
NOD	0.355	0.355
NZO	0.701	0.701
PWK	0.381	0.381
H37Rv_KO_CtpC	0.606	0.606
H37Rv_KO_CtpD	0.991	0.991
H37Rv_KO_Rv1272	0.351	0.351
H37Rv_KO_SugABC	0.801	0.801
H37Rv_KO_MbtN	0.503	0.503
Trans05	0.821	0.821
macrophage_unactivated	-0.316	-0.316
IL1	0.4	0.4
Rapamycin	-0.018	-0.018
Tcell	-0.189	-0.189
GMCSF	0.259	0.259
IFNab	-0.393	-0.393
IFNg	-0.016	-0.016
IFNg_GMCSF1	0.537	0.537
Rv1432_day32	0.863	0.863
Rv1565c_day32	-0.15	-0.15
secA2_input	-0.341	-0.341
delta_Rv3594	0.347	0.347
delta_Rv3717	0.693	0.693
delta_Rv3811	0.338	0.338
delta_Rv0954	0.252	0.252
PonA1	0.066	0.066
EccD1_KO	-0.796	-0.796
EspI_KO	-0.391	-0.391
PE35_KO	0.263	0.263
PPE68_KO	-0.25	-0.25
glycerol2	0.425	0.425
lignocerate	0.546	0.546
oleate	0.047	0.047
phosphatidylcholine	0.223	0.223
acetate	0.183	0.183
glucAc	0.406	0.406
Rv0950ko	-0.311	-0.311
Rv1096ko	-0.51	-0.51
Rv3684ko	-0.269	-0.269
delta_otsA_trehalose	-0.648	-0.648