TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2255c/-:
none

Correlation of Rv2255c/- with Rv2255c/-

Normalized LFCs for Rv2255c/-:
(description and provenance of datasets)

	Rv2255c/-	Rv2255c/-
Fe_supp_jason_reseq	3.525	3.525
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-1.272	-1.272
Rifampicin4	-2.708	-2.708
Ethambutol3	-0.793	-0.793
Meropenem3	-0.781	-0.781
Vancomycin16	-2.014	-2.014
Rv2680_day32	-0.131	-0.131
H37Rv_KO_MarP	-0.214	-0.214
hypoxia_3wks	2.113	2.113
hypoxia_6wks	1.432	1.432
glycerol	-2.108	-2.108
cholesterol	-2.021	-2.021
AJ	-2.254	-2.254
Bibs02	-2.551	-2.551
Bibs02c	2.836	2.836
BL6	-1.62	-1.62
BL6a	0.911	0.911
BXD01	0.427	0.427
BXD010	2.563	2.563
BXD011	0.443	0.443
BXD03	-1.222	-1.222
BXD04	1.8	1.8
BXD05	-1.307	-1.307
BXD06	1.715	1.715
BXD07	0.397	0.397
BXD08	1.119	1.119
BXD09	1.018	1.018
CAST	-1.208	-1.208
CCcont	-1.673	-1.673
DS01	-1.033	-1.033
DS02	-1.459	-1.459
DS04	-2.025	-2.025
DS0c	-1.823	-1.823
GP01	0.152	0.152
GP02	0.892	0.892
GP0c	0.399	0.399
NOD	-3.134	-3.134
NZO	0.881	0.881
PWK	-1.905	-1.905
H37Rv_KO_CtpC	-1.82	-1.82
H37Rv_KO_CtpD	-0.035	-0.035
H37Rv_KO_Rv1272	-1.101	-1.101
H37Rv_KO_SugABC	-0.962	-0.962
H37Rv_KO_MbtN	-0.408	-0.408
Trans05	-1.364	-1.364
macrophage_unactivated	-4.062	-4.062
IL1	1.851	1.851
Rapamycin	1.255	1.255
Tcell	-0.841	-0.841
GMCSF	0.415	0.415
IFNab	-2.422	-2.422
IFNg	-0.329	-0.329
IFNg_GMCSF1	0.072	0.072
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-6.0	-6.0
delta_Rv3594	5.189	5.189
delta_Rv3717	1.258	1.258
delta_Rv3811	2.687	2.687
delta_Rv0954	5.073	5.073
PonA1	0.0	0.0
EccD1_KO	0.52	0.52
EspI_KO	-3.568	-3.568
PE35_KO	1.07	1.07
PPE68_KO	0.131	0.131
glycerol2	-2.376	-2.376
lignocerate	-2.618	-2.618
oleate	-1.225	-1.225
phosphatidylcholine	-1.333	-1.333
acetate	-2.648	-2.648
glucAc	-5.915	-5.915
Rv0950ko	1.067	1.067
Rv1096ko	2.413	2.413
Rv3684ko	4.795	4.795
delta_otsA_trehalose	-1.661	-1.661