TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2146c/-:
none

Correlation of Rv2146c/- with Rv2146c/-

Normalized LFCs for Rv2146c/-:
(description and provenance of datasets)

	Rv2146c/-	Rv2146c/-
Fe_supp_jason_reseq	-2.0	-2.0
low_pH_jason_reseq	-4.927	-4.927
NO_jason_reseq	-0.761	-0.761
B6_jason_reseq	-3.268	-3.268
MHCII_jason_reseq	-0.667	-0.667
Isoniazid02	0.918	0.918
Rifampicin4	-2.272	-2.272
Ethambutol3	0.73	0.73
Meropenem3	0.226	0.226
Vancomycin16	-0.167	-0.167
Rv2680_day32	-0.131	-0.131
H37Rv_KO_MarP	-6.0	-6.0
hypoxia_3wks	2.568	2.568
hypoxia_6wks	-1.27	-1.27
glycerol	-0.075	-0.075
cholesterol	1.221	1.221
AJ	-0.086	-0.086
Bibs02	-2.035	-2.035
Bibs02c	1.438	1.438
BL6	2.422	2.422
BL6a	1.435	1.435
BXD01	0.714	0.714
BXD010	1.217	1.217
BXD011	1.192	1.192
BXD03	-1.505	-1.505
BXD04	-1.376	-1.376
BXD05	2.644	2.644
BXD06	0.0	0.0
BXD07	0.502	0.502
BXD08	-1.116	-1.116
BXD09	0.233	0.233
CAST	-0.172	-0.172
CCcont	2.377	2.377
DS01	0.667	0.667
DS02	2.278	2.278
DS04	1.334	1.334
DS0c	-0.627	-0.627
GP01	-0.828	-0.828
GP02	2.377	2.377
GP0c	0.046	0.046
NOD	-0.993	-0.993
NZO	0.564	0.564
PWK	0.136	0.136
H37Rv_KO_CtpC	1.086	1.086
H37Rv_KO_CtpD	0.64	0.64
H37Rv_KO_Rv1272	1.924	1.924
H37Rv_KO_SugABC	1.011	1.011
H37Rv_KO_MbtN	-1.147	-1.147
Trans05	0.134	0.134
macrophage_unactivated	1.846	1.846
IL1	-1.528	-1.528
Rapamycin	-0.227	-0.227
Tcell	2.353	2.353
GMCSF	1.415	1.415
IFNab	-2.606	-2.606
IFNg	-0.198	-0.198
IFNg_GMCSF1	4.063	4.063
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-4.195	-4.195
delta_Rv3594	3.93	3.93
delta_Rv3717	5.003	5.003
delta_Rv3811	4.134	4.134
delta_Rv0954	2.282	2.282
PonA1	1.262	1.262
EccD1_KO	-0.319	-0.319
EspI_KO	2.341	2.341
PE35_KO	1.867	1.867
PPE68_KO	-2.796	-2.796
glycerol2	0.95	0.95
lignocerate	0.0	0.0
oleate	0.196	0.196
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	-1.26	-1.26
Rv1096ko	-1.918	-1.918
Rv3684ko	-3.242	-3.242
delta_otsA_trehalose	-2.894	-2.894