TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2132/-:
none

Correlation of Rv2132/- with Rv2132/-

Normalized LFCs for Rv2132/-:
(description and provenance of datasets)

	Rv2132/-	Rv2132/-
Fe_supp_jason_reseq	-1.733	-1.733
low_pH_jason_reseq	-1.437	-1.437
NO_jason_reseq	0.549	0.549
B6_jason_reseq	0.335	0.335
MHCII_jason_reseq	-0.094	-0.094
Isoniazid02	0.356	0.356
Rifampicin4	0.311	0.311
Ethambutol3	-0.112	-0.112
Meropenem3	-0.217	-0.217
Vancomycin16	0.379	0.379
Rv2680_day32	0.39	0.39
H37Rv_KO_MarP	1.288	1.288
hypoxia_3wks	-0.61	-0.61
hypoxia_6wks	-0.399	-0.399
glycerol	0.025	0.025
cholesterol	-0.984	-0.984
AJ	0.661	0.661
Bibs02	0.897	0.897
Bibs02c	-0.236	-0.236
BL6	-0.743	-0.743
BL6a	-0.046	-0.046
BXD01	-0.864	-0.864
BXD010	-0.733	-0.733
BXD011	-1.081	-1.081
BXD03	0.277	0.277
BXD04	-0.855	-0.855
BXD05	0.329	0.329
BXD06	-0.399	-0.399
BXD07	-0.627	-0.627
BXD08	0.503	0.503
BXD09	-0.195	-0.195
CAST	-0.244	-0.244
CCcont	-0.447	-0.447
DS01	0.159	0.159
DS02	-0.339	-0.339
DS04	-1.54	-1.54
DS0c	-0.446	-0.446
GP01	0.539	0.539
GP02	0.61	0.61
GP0c	0.876	0.876
NOD	1.788	1.788
NZO	0.371	0.371
PWK	0.33	0.33
H37Rv_KO_CtpC	0.434	0.434
H37Rv_KO_CtpD	1.228	1.228
H37Rv_KO_Rv1272	1.055	1.055
H37Rv_KO_SugABC	-1.089	-1.089
H37Rv_KO_MbtN	-1.917	-1.917
Trans05	0.43	0.43
macrophage_unactivated	1.187	1.187
IL1	0.03	0.03
Rapamycin	1.0	1.0
Tcell	-0.062	-0.062
GMCSF	0.349	0.349
IFNab	1.131	1.131
IFNg	0.815	0.815
IFNg_GMCSF1	-0.031	-0.031
Rv1432_day32	0.132	0.132
Rv1565c_day32	-0.088	-0.088
secA2_input	1.208	1.208
delta_Rv3594	-0.145	-0.145
delta_Rv3717	-1.604	-1.604
delta_Rv3811	0.534	0.534
delta_Rv0954	0.475	0.475
PonA1	-0.04	-0.04
EccD1_KO	0.296	0.296
EspI_KO	0.536	0.536
PE35_KO	1.205	1.205
PPE68_KO	0.486	0.486
glycerol2	0.132	0.132
lignocerate	0.216	0.216
oleate	0.233	0.233
phosphatidylcholine	0.737	0.737
acetate	0.62	0.62
glucAc	0.17	0.17
Rv0950ko	0.805	0.805
Rv1096ko	1.354	1.354
Rv3684ko	0.982	0.982
delta_otsA_trehalose	0.452	0.452