TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2108/PPE36:
none

Correlation of Rv2108/PPE36 with Rv2108/PPE36

Normalized LFCs for Rv2108/PPE36:
(description and provenance of datasets)

	Rv2108/PPE36	Rv2108/PPE36
Fe_supp_jason_reseq	-0.521	-0.521
low_pH_jason_reseq	-0.328	-0.328
NO_jason_reseq	0.158	0.158
B6_jason_reseq	-0.49	-0.49
MHCII_jason_reseq	-0.53	-0.53
Isoniazid02	-0.56	-0.56
Rifampicin4	0.249	0.249
Ethambutol3	0.722	0.722
Meropenem3	0.025	0.025
Vancomycin16	-0.26	-0.26
Rv2680_day32	-0.767	-0.767
H37Rv_KO_MarP	-0.255	-0.255
hypoxia_3wks	-0.187	-0.187
hypoxia_6wks	-0.641	-0.641
glycerol	-0.143	-0.143
cholesterol	0.083	0.083
AJ	0.111	0.111
Bibs02	-0.474	-0.474
Bibs02c	0.349	0.349
BL6	0.188	0.188
BL6a	0.149	0.149
BXD01	0.08	0.08
BXD010	0.067	0.067
BXD011	0.681	0.681
BXD03	0.405	0.405
BXD04	0.0	0.0
BXD05	0.295	0.295
BXD06	-0.166	-0.166
BXD07	0.166	0.166
BXD08	0.363	0.363
BXD09	0.331	0.331
CAST	0.088	0.088
CCcont	0.008	0.008
DS01	0.423	0.423
DS02	0.362	0.362
DS04	-0.616	-0.616
DS0c	0.113	0.113
GP01	0.07	0.07
GP02	-0.012	-0.012
GP0c	-0.032	-0.032
NOD	0.908	0.908
NZO	0.429	0.429
PWK	0.209	0.209
H37Rv_KO_CtpC	0.457	0.457
H37Rv_KO_CtpD	1.025	1.025
H37Rv_KO_Rv1272	1.119	1.119
H37Rv_KO_SugABC	0.3	0.3
H37Rv_KO_MbtN	0.697	0.697
Trans05	1.071	1.071
macrophage_unactivated	0.521	0.521
IL1	-0.303	-0.303
Rapamycin	0.227	0.227
Tcell	-0.28	-0.28
GMCSF	-0.121	-0.121
IFNab	-0.408	-0.408
IFNg	-0.23	-0.23
IFNg_GMCSF1	0.581	0.581
Rv1432_day32	0.33	0.33
Rv1565c_day32	0.273	0.273
secA2_input	-0.05	-0.05
delta_Rv3594	0.517	0.517
delta_Rv3717	0.039	0.039
delta_Rv3811	0.488	0.488
delta_Rv0954	0.598	0.598
PonA1	-0.472	-0.472
EccD1_KO	0.398	0.398
EspI_KO	0.539	0.539
PE35_KO	0.487	0.487
PPE68_KO	0.71	0.71
glycerol2	0.468	0.468
lignocerate	0.51	0.51
oleate	0.065	0.065
phosphatidylcholine	0.503	0.503
acetate	0.283	0.283
glucAc	0.319	0.319
Rv0950ko	0.163	0.163
Rv1096ko	-0.534	-0.534
Rv3684ko	0.534	0.534
delta_otsA_trehalose	0.154	0.154