TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2084/-:
none

Correlation of Rv2084/- with Rv2084/-

Normalized LFCs for Rv2084/-:
(description and provenance of datasets)

	Rv2084/-	Rv2084/-
Fe_supp_jason_reseq	-0.579	-0.579
low_pH_jason_reseq	0.908	0.908
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.345	0.345
MHCII_jason_reseq	0.338	0.338
Isoniazid02	-0.928	-0.928
Rifampicin4	0.097	0.097
Ethambutol3	0.393	0.393
Meropenem3	-0.304	-0.304
Vancomycin16	-0.395	-0.395
Rv2680_day32	-0.109	-0.109
H37Rv_KO_MarP	0.082	0.082
hypoxia_3wks	-0.51	-0.51
hypoxia_6wks	0.43	0.43
glycerol	-0.348	-0.348
cholesterol	0.0	0.0
AJ	0.329	0.329
Bibs02	-0.151	-0.151
Bibs02c	-0.173	-0.173
BL6	0.384	0.384
BL6a	-0.342	-0.342
BXD01	-0.432	-0.432
BXD010	-0.379	-0.379
BXD011	-0.458	-0.458
BXD03	0.906	0.906
BXD04	-0.617	-0.617
BXD05	-0.242	-0.242
BXD06	-0.272	-0.272
BXD07	-0.434	-0.434
BXD08	-0.303	-0.303
BXD09	-0.076	-0.076
CAST	-0.093	-0.093
CCcont	-0.51	-0.51
DS01	-0.128	-0.128
DS02	-0.307	-0.307
DS04	0.089	0.089
DS0c	-0.058	-0.058
GP01	-0.346	-0.346
GP02	0.187	0.187
GP0c	-0.385	-0.385
NOD	0.073	0.073
NZO	0.129	0.129
PWK	-0.634	-0.634
H37Rv_KO_CtpC	-0.122	-0.122
H37Rv_KO_CtpD	0.462	0.462
H37Rv_KO_Rv1272	0.664	0.664
H37Rv_KO_SugABC	-0.027	-0.027
H37Rv_KO_MbtN	0.286	0.286
Trans05	0.791	0.791
macrophage_unactivated	0.29	0.29
IL1	-0.193	-0.193
Rapamycin	0.715	0.715
Tcell	-0.036	-0.036
GMCSF	0.217	0.217
IFNab	0.157	0.157
IFNg	0.989	0.989
IFNg_GMCSF1	0.38	0.38
Rv1432_day32	0.239	0.239
Rv1565c_day32	0.368	0.368
secA2_input	0.515	0.515
delta_Rv3594	-0.548	-0.548
delta_Rv3717	-0.159	-0.159
delta_Rv3811	-0.394	-0.394
delta_Rv0954	-0.296	-0.296
PonA1	-0.425	-0.425
EccD1_KO	0.263	0.263
EspI_KO	0.143	0.143
PE35_KO	-0.061	-0.061
PPE68_KO	0.128	0.128
glycerol2	-0.198	-0.198
lignocerate	0.024	0.024
oleate	-0.136	-0.136
phosphatidylcholine	-0.119	-0.119
acetate	-0.783	-0.783
glucAc	-0.61	-0.61
Rv0950ko	0.13	0.13
Rv1096ko	0.0	0.0
Rv3684ko	-0.37	-0.37
delta_otsA_trehalose	-0.485	-0.485