TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2054/-:
none

Correlation of Rv2054/- with Rv2054/-

Normalized LFCs for Rv2054/-:
(description and provenance of datasets)

	Rv2054/-	Rv2054/-
Fe_supp_jason_reseq	0.428	0.428
low_pH_jason_reseq	-0.149	-0.149
NO_jason_reseq	0.488	0.488
B6_jason_reseq	0.162	0.162
MHCII_jason_reseq	-0.184	-0.184
Isoniazid02	0.57	0.57
Rifampicin4	-0.014	-0.014
Ethambutol3	0.06	0.06
Meropenem3	0.237	0.237
Vancomycin16	-0.297	-0.297
Rv2680_day32	0.681	0.681
H37Rv_KO_MarP	-0.049	-0.049
hypoxia_3wks	-0.1	-0.1
hypoxia_6wks	-0.226	-0.226
glycerol	-0.275	-0.275
cholesterol	0.219	0.219
AJ	0.619	0.619
Bibs02	-0.024	-0.024
Bibs02c	0.668	0.668
BL6	-0.166	-0.166
BL6a	0.116	0.116
BXD01	0.187	0.187
BXD010	0.106	0.106
BXD011	0.261	0.261
BXD03	-0.681	-0.681
BXD04	-0.291	-0.291
BXD05	0.196	0.196
BXD06	0.021	0.021
BXD07	0.052	0.052
BXD08	0.05	0.05
BXD09	-0.122	-0.122
CAST	-0.015	-0.015
CCcont	-0.633	-0.633
DS01	0.038	0.038
DS02	0.102	0.102
DS04	-0.236	-0.236
DS0c	0.273	0.273
GP01	0.361	0.361
GP02	0.6	0.6
GP0c	0.146	0.146
NOD	0.744	0.744
NZO	0.081	0.081
PWK	0.533	0.533
H37Rv_KO_CtpC	-0.053	-0.053
H37Rv_KO_CtpD	0.195	0.195
H37Rv_KO_Rv1272	0.467	0.467
H37Rv_KO_SugABC	-0.241	-0.241
H37Rv_KO_MbtN	0.285	0.285
Trans05	0.513	0.513
macrophage_unactivated	-0.17	-0.17
IL1	0.0	0.0
Rapamycin	-0.104	-0.104
Tcell	-0.209	-0.209
GMCSF	-0.549	-0.549
IFNab	-0.511	-0.511
IFNg	0.078	0.078
IFNg_GMCSF1	0.267	0.267
Rv1432_day32	0.313	0.313
Rv1565c_day32	-0.36	-0.36
secA2_input	-0.111	-0.111
delta_Rv3594	0.295	0.295
delta_Rv3717	0.425	0.425
delta_Rv3811	0.178	0.178
delta_Rv0954	0.363	0.363
PonA1	0.355	0.355
EccD1_KO	-0.437	-0.437
EspI_KO	-0.322	-0.322
PE35_KO	-0.414	-0.414
PPE68_KO	-0.634	-0.634
glycerol2	0.603	0.603
lignocerate	0.099	0.099
oleate	1.007	1.007
phosphatidylcholine	0.735	0.735
acetate	-0.304	-0.304
glucAc	-0.87	-0.87
Rv0950ko	0.76	0.76
Rv1096ko	0.443	0.443
Rv3684ko	0.131	0.131
delta_otsA_trehalose	0.151	0.151