TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2049c/-:
none

Correlation of Rv2049c/- with Rv2049c/-

Normalized LFCs for Rv2049c/-:
(description and provenance of datasets)

	Rv2049c/-	Rv2049c/-
Fe_supp_jason_reseq	-3.995	-3.995
low_pH_jason_reseq	-1.486	-1.486
NO_jason_reseq	0.57	0.57
B6_jason_reseq	0.077	0.077
MHCII_jason_reseq	-1.475	-1.475
Isoniazid02	0.0	0.0
Rifampicin4	2.02	2.02
Ethambutol3	0.817	0.817
Meropenem3	3.645	3.645
Vancomycin16	0.194	0.194
Rv2680_day32	-1.907	-1.907
H37Rv_KO_MarP	1.731	1.731
hypoxia_3wks	-1.42	-1.42
hypoxia_6wks	-1.416	-1.416
glycerol	0.862	0.862
cholesterol	0.861	0.861
AJ	-1.403	-1.403
Bibs02	-1.454	-1.454
Bibs02c	-3.898	-3.898
BL6	-3.099	-3.099
BL6a	-4.907	-4.907
BXD01	-3.227	-3.227
BXD010	-3.173	-3.173
BXD011	-2.106	-2.106
BXD03	-3.35	-3.35
BXD04	-3.064	-3.064
BXD05	-3.2	-3.2
BXD06	-3.307	-3.307
BXD07	-3.43	-3.43
BXD08	-2.93	-2.93
BXD09	-3.482	-3.482
CAST	-2.309	-2.309
CCcont	-3.7	-3.7
DS01	0.749	0.749
DS02	-2.815	-2.815
DS04	0.0	0.0
DS0c	2.156	2.156
GP01	-2.446	-2.446
GP02	-2.061	-2.061
GP0c	-3.221	-3.221
NOD	-3.609	-3.609
NZO	-0.162	-0.162
PWK	-1.731	-1.731
H37Rv_KO_CtpC	1.645	1.645
H37Rv_KO_CtpD	-2.288	-2.288
H37Rv_KO_Rv1272	-3.494	-3.494
H37Rv_KO_SugABC	-1.967	-1.967
H37Rv_KO_MbtN	-1.144	-1.144
Trans05	-3.237	-3.237
macrophage_unactivated	-6.0	-6.0
IL1	-6.0	-6.0
Rapamycin	-6.0	-6.0
Tcell	-6.0	-6.0
GMCSF	-5.281	-5.281
IFNab	-6.0	-6.0
IFNg	-5.714	-5.714
IFNg_GMCSF1	-6.0	-6.0
Rv1432_day32	-0.763	-0.763
Rv1565c_day32	0.0	0.0
secA2_input	-1.94	-1.94
delta_Rv3594	1.144	1.144
delta_Rv3717	-1.515	-1.515
delta_Rv3811	-2.756	-2.756
delta_Rv0954	-1.124	-1.124
PonA1	1.012	1.012
EccD1_KO	0.26	0.26
EspI_KO	-1.263	-1.263
PE35_KO	0.379	0.379
PPE68_KO	1.081	1.081
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	-4.544	-4.544
Rv1096ko	-1.472	-1.472
Rv3684ko	0.616	0.616
delta_otsA_trehalose	2.212	2.212