TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1983/PE_PGRS35:
none

Correlation of Rv1983/PE_PGRS35 with Rv1983/PE_PGRS35

Normalized LFCs for Rv1983/PE_PGRS35:
(description and provenance of datasets)

	Rv1983/PE_PGRS35	Rv1983/PE_PGRS35
Fe_supp_jason_reseq	-0.06	-0.06
low_pH_jason_reseq	-0.636	-0.636
NO_jason_reseq	0.042	0.042
B6_jason_reseq	0.107	0.107
MHCII_jason_reseq	0.094	0.094
Isoniazid02	-0.454	-0.454
Rifampicin4	0.403	0.403
Ethambutol3	-0.499	-0.499
Meropenem3	-0.113	-0.113
Vancomycin16	-0.294	-0.294
Rv2680_day32	0.064	0.064
H37Rv_KO_MarP	0.298	0.298
hypoxia_3wks	-0.642	-0.642
hypoxia_6wks	-0.297	-0.297
glycerol	-0.17	-0.17
cholesterol	0.018	0.018
AJ	0.029	0.029
Bibs02	0.556	0.556
Bibs02c	0.418	0.418
BL6	0.513	0.513
BL6a	0.35	0.35
BXD01	0.078	0.078
BXD010	0.178	0.178
BXD011	0.066	0.066
BXD03	-0.029	-0.029
BXD04	0.393	0.393
BXD05	-0.207	-0.207
BXD06	0.19	0.19
BXD07	0.131	0.131
BXD08	-0.093	-0.093
BXD09	-0.026	-0.026
CAST	0.199	0.199
CCcont	-0.095	-0.095
DS01	-0.06	-0.06
DS02	0.079	0.079
DS04	0.195	0.195
DS0c	-0.317	-0.317
GP01	0.676	0.676
GP02	1.177	1.177
GP0c	0.047	0.047
NOD	-0.021	-0.021
NZO	-0.59	-0.59
PWK	0.129	0.129
H37Rv_KO_CtpC	0.551	0.551
H37Rv_KO_CtpD	0.256	0.256
H37Rv_KO_Rv1272	1.015	1.015
H37Rv_KO_SugABC	0.638	0.638
H37Rv_KO_MbtN	0.798	0.798
Trans05	0.649	0.649
macrophage_unactivated	0.186	0.186
IL1	0.332	0.332
Rapamycin	0.141	0.141
Tcell	-0.215	-0.215
GMCSF	0.417	0.417
IFNab	-0.2	-0.2
IFNg	-0.059	-0.059
IFNg_GMCSF1	0.487	0.487
Rv1432_day32	0.153	0.153
Rv1565c_day32	-0.324	-0.324
secA2_input	-0.388	-0.388
delta_Rv3594	-0.072	-0.072
delta_Rv3717	0.086	0.086
delta_Rv3811	0.097	0.097
delta_Rv0954	-0.353	-0.353
PonA1	-0.145	-0.145
EccD1_KO	0.622	0.622
EspI_KO	0.285	0.285
PE35_KO	0.551	0.551
PPE68_KO	0.691	0.691
glycerol2	0.657	0.657
lignocerate	1.213	1.213
oleate	0.282	0.282
phosphatidylcholine	0.926	0.926
acetate	0.745	0.745
glucAc	0.538	0.538
Rv0950ko	-0.096	-0.096
Rv1096ko	-0.546	-0.546
Rv3684ko	-0.779	-0.779
delta_otsA_trehalose	0.585	0.585