TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1952/vapB14:
none

Correlation of Rv1952/vapB14 with Rv1952/vapB14

Normalized LFCs for Rv1952/vapB14:
(description and provenance of datasets)

	Rv1952/vapB14	Rv1952/vapB14
Fe_supp_jason_reseq	-0.845	-0.845
low_pH_jason_reseq	0.788	0.788
NO_jason_reseq	0.131	0.131
B6_jason_reseq	0.091	0.091
MHCII_jason_reseq	1.17	1.17
Isoniazid02	-0.953	-0.953
Rifampicin4	-1.454	-1.454
Ethambutol3	-0.912	-0.912
Meropenem3	2.256	2.256
Vancomycin16	-1.502	-1.502
Rv2680_day32	-1.6	-1.6
H37Rv_KO_MarP	0.062	0.062
hypoxia_3wks	-0.255	-0.255
hypoxia_6wks	-1.0	-1.0
glycerol	0.0	0.0
cholesterol	0.165	0.165
AJ	-2.629	-2.629
Bibs02	-0.687	-0.687
Bibs02c	1.149	1.149
BL6	-3.441	-3.441
BL6a	-1.169	-1.169
BXD01	-1.238	-1.238
BXD010	0.368	0.368
BXD011	-0.564	-0.564
BXD03	-2.812	-2.812
BXD04	-1.246	-1.246
BXD05	-0.709	-0.709
BXD06	-0.252	-0.252
BXD07	-2.426	-2.426
BXD08	-0.684	-0.684
BXD09	-1.258	-1.258
CAST	1.116	1.116
CCcont	-3.699	-3.699
DS01	-0.166	-0.166
DS02	0.698	0.698
DS04	0.058	0.058
DS0c	0.361	0.361
GP01	-2.618	-2.618
GP02	-2.289	-2.289
GP0c	-1.693	-1.693
NOD	-0.086	-0.086
NZO	-2.131	-2.131
PWK	0.072	0.072
H37Rv_KO_CtpC	2.445	2.445
H37Rv_KO_CtpD	-0.039	-0.039
H37Rv_KO_Rv1272	0.608	0.608
H37Rv_KO_SugABC	-2.453	-2.453
H37Rv_KO_MbtN	-0.456	-0.456
Trans05	-0.956	-0.956
macrophage_unactivated	1.547	1.547
IL1	-0.842	-0.842
Rapamycin	0.592	0.592
Tcell	0.218	0.218
GMCSF	-1.827	-1.827
IFNab	1.055	1.055
IFNg	0.0	0.0
IFNg_GMCSF1	2.316	2.316
Rv1432_day32	-0.151	-0.151
Rv1565c_day32	-1.012	-1.012
secA2_input	-0.286	-0.286
delta_Rv3594	0.047	0.047
delta_Rv3717	-0.464	-0.464
delta_Rv3811	-2.998	-2.998
delta_Rv0954	-2.412	-2.412
PonA1	-1.324	-1.324
EccD1_KO	0.638	0.638
EspI_KO	0.673	0.673
PE35_KO	-0.487	-0.487
PPE68_KO	-0.755	-0.755
glycerol2	-0.377	-0.377
lignocerate	-1.025	-1.025
oleate	0.759	0.759
phosphatidylcholine	-0.514	-0.514
acetate	-0.673	-0.673
glucAc	-4.009	-4.009
Rv0950ko	0.552	0.552
Rv1096ko	-0.446	-0.446
Rv3684ko	-0.606	-0.606
delta_otsA_trehalose	0.28	0.28