TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1877/-:
none

Correlation of Rv1877/- with Rv1877/-

Normalized LFCs for Rv1877/-:
(description and provenance of datasets)

	Rv1877/-	Rv1877/-
Fe_supp_jason_reseq	-0.016	-0.016
low_pH_jason_reseq	-0.351	-0.351
NO_jason_reseq	0.026	0.026
B6_jason_reseq	0.233	0.233
MHCII_jason_reseq	0.248	0.248
Isoniazid02	1.419	1.419
Rifampicin4	0.119	0.119
Ethambutol3	1.468	1.468
Meropenem3	-0.042	-0.042
Vancomycin16	-0.244	-0.244
Rv2680_day32	0.212	0.212
H37Rv_KO_MarP	-0.174	-0.174
hypoxia_3wks	-0.255	-0.255
hypoxia_6wks	-0.309	-0.309
glycerol	0.007	0.007
cholesterol	-0.167	-0.167
AJ	-0.146	-0.146
Bibs02	0.261	0.261
Bibs02c	0.152	0.152
BL6	0.333	0.333
BL6a	-0.076	-0.076
BXD01	0.163	0.163
BXD010	-0.049	-0.049
BXD011	-0.118	-0.118
BXD03	-0.359	-0.359
BXD04	0.098	0.098
BXD05	-0.352	-0.352
BXD06	-0.154	-0.154
BXD07	0.005	0.005
BXD08	-0.173	-0.173
BXD09	-0.034	-0.034
CAST	0.13	0.13
CCcont	0.169	0.169
DS01	0.252	0.252
DS02	0.4	0.4
DS04	-0.23	-0.23
DS0c	0.278	0.278
GP01	0.333	0.333
GP02	0.275	0.275
GP0c	-0.026	-0.026
NOD	0.724	0.724
NZO	-0.354	-0.354
PWK	0.185	0.185
H37Rv_KO_CtpC	0.128	0.128
H37Rv_KO_CtpD	0.272	0.272
H37Rv_KO_Rv1272	0.243	0.243
H37Rv_KO_SugABC	0.783	0.783
H37Rv_KO_MbtN	0.343	0.343
Trans05	0.408	0.408
macrophage_unactivated	0.101	0.101
IL1	0.172	0.172
Rapamycin	-0.015	-0.015
Tcell	0.29	0.29
GMCSF	0.013	0.013
IFNab	-0.184	-0.184
IFNg	0.086	0.086
IFNg_GMCSF1	0.116	0.116
Rv1432_day32	0.123	0.123
Rv1565c_day32	0.415	0.415
secA2_input	-0.451	-0.451
delta_Rv3594	0.055	0.055
delta_Rv3717	0.089	0.089
delta_Rv3811	0.046	0.046
delta_Rv0954	0.079	0.079
PonA1	0.036	0.036
EccD1_KO	0.079	0.079
EspI_KO	-0.416	-0.416
PE35_KO	-0.426	-0.426
PPE68_KO	-0.518	-0.518
glycerol2	0.965	0.965
lignocerate	1.092	1.092
oleate	0.588	0.588
phosphatidylcholine	1.011	1.011
acetate	0.495	0.495
glucAc	0.396	0.396
Rv0950ko	0.302	0.302
Rv1096ko	0.368	0.368
Rv3684ko	0.075	0.075
delta_otsA_trehalose	-0.111	-0.111