TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1869c/-:

update plot	correlation	link to info on gene
Rv2955c/-	(cc=0.5335)	info on Rv2955c/-
Rv2270/lppN	(cc=0.5133)	info on Rv2270/lppN
Rv2293c/-	(cc=0.482)	info on Rv2293c/-
Rv2128/-	(cc=0.4808)	info on Rv2128/-
Rv1121/zwf1	(cc=0.4784)	info on Rv1121/zwf1
Rv2972c/-	(cc=0.4548)	info on Rv2972c/-
Rv2267c/-	(cc=0.4481)	info on Rv2267c/-
Rv2041c/-	(cc=0.4468)	info on Rv2041c/-
Rv2956/-	(cc=0.4463)	info on Rv2956/-
Rv2470/glbO	(cc=0.4347)	info on Rv2470/glbO

Correlation of Rv1869c/- with Rv2955c/-

Normalized LFCs for Rv1869c/-:
(description and provenance of datasets)

	Rv1869c/-	Rv2955c/-
Fe_supp_jason_reseq	0.013	-0.931
low_pH_jason_reseq	-0.112	0.649
NO_jason_reseq	0.27	-0.026
B6_jason_reseq	0.14	-0.206
MHCII_jason_reseq	0.812	0.575
Isoniazid02	0.447	0.185
Rifampicin4	-0.33	0.644
Ethambutol3	0.34	0.66
Meropenem3	1.387	2.825
Vancomycin16	0.066	0.162
Rv2680_day32	0.525	-0.117
H37Rv_KO_MarP	0.157	-0.063
hypoxia_3wks	0.0	0.251
hypoxia_6wks	0.443	0.0
glycerol	-0.661	0.87
cholesterol	-0.725	0.101
AJ	0.449	0.511
Bibs02	-0.029	0.576
Bibs02c	0.32	-0.189
BL6	-0.132	-0.258
BL6a	0.518	-0.118
BXD01	-0.108	0.396
BXD010	0.397	0.326
BXD011	0.444	-0.417
BXD03	0.09	-0.08
BXD04	0.172	0.509
BXD05	0.51	0.256
BXD06	0.141	-0.059
BXD07	0.237	-0.071
BXD08	0.417	0.541
BXD09	0.379	-0.01
CAST	0.33	-0.102
CCcont	-0.267	-0.183
DS01	0.339	-0.233
DS02	0.282	0.454
DS04	0.159	0.096
DS0c	0.046	0.181
GP01	-0.117	-0.893
GP02	-0.103	0.041
GP0c	-0.618	-0.118
NOD	-0.011	0.033
NZO	0.42	0.802
PWK	0.72	0.466
H37Rv_KO_CtpC	-0.271	0.091
H37Rv_KO_CtpD	0.557	0.218
H37Rv_KO_Rv1272	0.475	-1.094
H37Rv_KO_SugABC	0.357	0.441
H37Rv_KO_MbtN	0.022	0.547
Trans05	0.405	0.473
macrophage_unactivated	-0.786	-0.877
IL1	-0.092	0.107
Rapamycin	0.095	-0.169
Tcell	-0.837	-0.661
GMCSF	-0.288	-0.048
IFNab	0.272	-0.52
IFNg	-0.016	-0.072
IFNg_GMCSF1	0.135	0.057
Rv1432_day32	0.098	0.9
Rv1565c_day32	-1.27	-1.208
secA2_input	-0.153	-0.099
delta_Rv3594	0.541	-0.288
delta_Rv3717	0.023	-0.677
delta_Rv3811	0.495	-0.464
delta_Rv0954	0.253	0.111
PonA1	0.132	-0.466
EccD1_KO	0.812	0.194
EspI_KO	0.796	1.027
PE35_KO	0.624	0.968
PPE68_KO	0.893	0.937
glycerol2	-0.398	-0.722
lignocerate	-0.326	-0.887
oleate	-0.242	-0.305
phosphatidylcholine	-0.375	-0.612
acetate	-0.421	-1.006
glucAc	-0.648	-0.933
Rv0950ko	-0.151	-0.823
Rv1096ko	-0.609	-0.283
Rv3684ko	-0.275	-1.307
delta_otsA_trehalose	1.056	-0.081