TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1851/ureF:
none

Correlation of Rv1851/ureF with Rv1851/ureF

Normalized LFCs for Rv1851/ureF:
(description and provenance of datasets)

	Rv1851/ureF	Rv1851/ureF
Fe_supp_jason_reseq	-1.407	-1.407
low_pH_jason_reseq	-1.144	-1.144
NO_jason_reseq	-0.475	-0.475
B6_jason_reseq	-1.206	-1.206
MHCII_jason_reseq	-0.249	-0.249
Isoniazid02	0.138	0.138
Rifampicin4	0.116	0.116
Ethambutol3	-0.272	-0.272
Meropenem3	-0.379	-0.379
Vancomycin16	0.711	0.711
Rv2680_day32	-1.646	-1.646
H37Rv_KO_MarP	0.09	0.09
hypoxia_3wks	-0.247	-0.247
hypoxia_6wks	-1.119	-1.119
glycerol	-1.477	-1.477
cholesterol	0.249	0.249
AJ	2.679	2.679
Bibs02	1.009	1.009
Bibs02c	-1.388	-1.388
BL6	0.444	0.444
BL6a	-1.095	-1.095
BXD01	-0.123	-0.123
BXD010	0.127	0.127
BXD011	1.228	1.228
BXD03	1.631	1.631
BXD04	0.13	0.13
BXD05	0.975	0.975
BXD06	-1.133	-1.133
BXD07	-0.655	-0.655
BXD08	-0.166	-0.166
BXD09	-0.439	-0.439
CAST	0.229	0.229
CCcont	0.793	0.793
DS01	1.244	1.244
DS02	-0.394	-0.394
DS04	2.209	2.209
DS0c	1.059	1.059
GP01	-2.801	-2.801
GP02	-2.36	-2.36
GP0c	-3.441	-3.441
NOD	-0.618	-0.618
NZO	1.617	1.617
PWK	0.503	0.503
H37Rv_KO_CtpC	-0.28	-0.28
H37Rv_KO_CtpD	-2.279	-2.279
H37Rv_KO_Rv1272	0.131	0.131
H37Rv_KO_SugABC	-1.639	-1.639
H37Rv_KO_MbtN	-2.075	-2.075
Trans05	0.27	0.27
macrophage_unactivated	-1.774	-1.774
IL1	0.792	0.792
Rapamycin	0.0	0.0
Tcell	-1.887	-1.887
GMCSF	-0.016	-0.016
IFNab	0.629	0.629
IFNg	-0.492	-0.492
IFNg_GMCSF1	0.528	0.528
Rv1432_day32	-0.751	-0.751
Rv1565c_day32	0.0	0.0
secA2_input	1.797	1.797
delta_Rv3594	1.062	1.062
delta_Rv3717	-0.527	-0.527
delta_Rv3811	1.37	1.37
delta_Rv0954	0.43	0.43
PonA1	-3.214	-3.214
EccD1_KO	0.881	0.881
EspI_KO	-0.585	-0.585
PE35_KO	0.887	0.887
PPE68_KO	2.057	2.057
glycerol2	-0.398	-0.398
lignocerate	-0.072	-0.072
oleate	0.313	0.313
phosphatidylcholine	0.206	0.206
acetate	0.833	0.833
glucAc	0.013	0.013
Rv0950ko	1.562	1.562
Rv1096ko	3.227	3.227
Rv3684ko	3.475	3.475
delta_otsA_trehalose	-2.701	-2.701