TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1835c/-:
none

Correlation of Rv1835c/- with Rv1835c/-

Normalized LFCs for Rv1835c/-:
(description and provenance of datasets)

	Rv1835c/-	Rv1835c/-
Fe_supp_jason_reseq	-0.052	-0.052
low_pH_jason_reseq	0.095	0.095
NO_jason_reseq	0.2	0.2
B6_jason_reseq	-0.507	-0.507
MHCII_jason_reseq	-0.108	-0.108
Isoniazid02	0.828	0.828
Rifampicin4	0.187	0.187
Ethambutol3	0.53	0.53
Meropenem3	0.885	0.885
Vancomycin16	-0.117	-0.117
Rv2680_day32	-0.042	-0.042
H37Rv_KO_MarP	0.047	0.047
hypoxia_3wks	0.215	0.215
hypoxia_6wks	-0.019	-0.019
glycerol	-0.048	-0.048
cholesterol	-0.154	-0.154
AJ	-0.092	-0.092
Bibs02	-0.05	-0.05
Bibs02c	0.126	0.126
BL6	0.732	0.732
BL6a	0.22	0.22
BXD01	0.343	0.343
BXD010	0.228	0.228
BXD011	0.508	0.508
BXD03	0.196	0.196
BXD04	0.362	0.362
BXD05	0.489	0.489
BXD06	0.347	0.347
BXD07	0.538	0.538
BXD08	0.424	0.424
BXD09	0.553	0.553
CAST	0.18	0.18
CCcont	0.196	0.196
DS01	0.055	0.055
DS02	-0.175	-0.175
DS04	0.074	0.074
DS0c	0.284	0.284
GP01	-0.157	-0.157
GP02	0.356	0.356
GP0c	-0.015	-0.015
NOD	1.007	1.007
NZO	0.12	0.12
PWK	0.153	0.153
H37Rv_KO_CtpC	0.661	0.661
H37Rv_KO_CtpD	-0.261	-0.261
H37Rv_KO_Rv1272	0.791	0.791
H37Rv_KO_SugABC	0.936	0.936
H37Rv_KO_MbtN	0.482	0.482
Trans05	1.052	1.052
macrophage_unactivated	0.328	0.328
IL1	0.457	0.457
Rapamycin	0.203	0.203
Tcell	0.016	0.016
GMCSF	0.544	0.544
IFNab	0.067	0.067
IFNg	-0.184	-0.184
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.213	0.213
Rv1565c_day32	0.163	0.163
secA2_input	-0.302	-0.302
delta_Rv3594	-0.174	-0.174
delta_Rv3717	0.038	0.038
delta_Rv3811	0.025	0.025
delta_Rv0954	0.173	0.173
PonA1	-0.394	-0.394
EccD1_KO	0.579	0.579
EspI_KO	-0.04	-0.04
PE35_KO	-0.015	-0.015
PPE68_KO	-0.045	-0.045
glycerol2	0.645	0.645
lignocerate	0.667	0.667
oleate	0.871	0.871
phosphatidylcholine	0.961	0.961
acetate	-0.027	-0.027
glucAc	0.18	0.18
Rv0950ko	0.045	0.045
Rv1096ko	-0.187	-0.187
Rv3684ko	-0.38	-0.38
delta_otsA_trehalose	-0.216	-0.216