TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1786/-:
none

Correlation of Rv1786/- with Rv1786/-

Normalized LFCs for Rv1786/-:
(description and provenance of datasets)

	Rv1786/-	Rv1786/-
Fe_supp_jason_reseq	1.844	1.844
low_pH_jason_reseq	0.519	0.519
NO_jason_reseq	-1.037	-1.037
B6_jason_reseq	0.523	0.523
MHCII_jason_reseq	-0.186	-0.186
Isoniazid02	-0.8	-0.8
Rifampicin4	-1.484	-1.484
Ethambutol3	2.512	2.512
Meropenem3	-1.158	-1.158
Vancomycin16	-0.796	-0.796
Rv2680_day32	-0.004	-0.004
H37Rv_KO_MarP	0.595	0.595
hypoxia_3wks	-0.251	-0.251
hypoxia_6wks	-0.643	-0.643
glycerol	0.105	0.105
cholesterol	0.343	0.343
AJ	-0.613	-0.613
Bibs02	1.368	1.368
Bibs02c	-0.17	-0.17
BL6	1.487	1.487
BL6a	0.862	0.862
BXD01	1.609	1.609
BXD010	2.004	2.004
BXD011	1.396	1.396
BXD03	1.914	1.914
BXD04	0.72	0.72
BXD05	2.52	2.52
BXD06	1.304	1.304
BXD07	1.442	1.442
BXD08	0.417	0.417
BXD09	1.264	1.264
CAST	-0.477	-0.477
CCcont	1.946	1.946
DS01	0.601	0.601
DS02	1.3	1.3
DS04	0.212	0.212
DS0c	0.574	0.574
GP01	2.286	2.286
GP02	1.54	1.54
GP0c	1.155	1.155
NOD	-1.957	-1.957
NZO	-0.955	-0.955
PWK	-1.523	-1.523
H37Rv_KO_CtpC	1.28	1.28
H37Rv_KO_CtpD	2.22	2.22
H37Rv_KO_Rv1272	0.87	0.87
H37Rv_KO_SugABC	-1.05	-1.05
H37Rv_KO_MbtN	1.429	1.429
Trans05	1.242	1.242
macrophage_unactivated	0.505	0.505
IL1	-0.068	-0.068
Rapamycin	0.537	0.537
Tcell	-1.906	-1.906
GMCSF	-0.33	-0.33
IFNab	1.004	1.004
IFNg	0.281	0.281
IFNg_GMCSF1	0.141	0.141
Rv1432_day32	0.999	0.999
Rv1565c_day32	-0.31	-0.31
secA2_input	-1.933	-1.933
delta_Rv3594	-0.517	-0.517
delta_Rv3717	0.38	0.38
delta_Rv3811	0.388	0.388
delta_Rv0954	-0.203	-0.203
PonA1	0.467	0.467
EccD1_KO	-0.076	-0.076
EspI_KO	1.472	1.472
PE35_KO	0.496	0.496
PPE68_KO	0.982	0.982
glycerol2	1.356	1.356
lignocerate	1.303	1.303
oleate	0.74	0.74
phosphatidylcholine	1.395	1.395
acetate	0.351	0.351
glucAc	0.554	0.554
Rv0950ko	0.754	0.754
Rv1096ko	-0.844	-0.844
Rv3684ko	-0.632	-0.632
delta_otsA_trehalose	1.87	1.87