TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1723/-:
none

Correlation of Rv1723/- with Rv1723/-

Normalized LFCs for Rv1723/-:
(description and provenance of datasets)

	Rv1723/-	Rv1723/-
Fe_supp_jason_reseq	-0.474	-0.474
low_pH_jason_reseq	-0.44	-0.44
NO_jason_reseq	-0.331	-0.331
B6_jason_reseq	-0.229	-0.229
MHCII_jason_reseq	0.281	0.281
Isoniazid02	0.138	0.138
Rifampicin4	-0.016	-0.016
Ethambutol3	-0.197	-0.197
Meropenem3	0.327	0.327
Vancomycin16	0.016	0.016
Rv2680_day32	-0.07	-0.07
H37Rv_KO_MarP	0.083	0.083
hypoxia_3wks	0.064	0.064
hypoxia_6wks	-0.75	-0.75
glycerol	-0.042	-0.042
cholesterol	-0.184	-0.184
AJ	-0.018	-0.018
Bibs02	0.074	0.074
Bibs02c	-0.534	-0.534
BL6	-1.401	-1.401
BL6a	-1.036	-1.036
BXD01	-1.114	-1.114
BXD010	-1.037	-1.037
BXD011	-0.684	-0.684
BXD03	-0.883	-0.883
BXD04	-0.959	-0.959
BXD05	-1.02	-1.02
BXD06	-1.181	-1.181
BXD07	-0.883	-0.883
BXD08	-0.617	-0.617
BXD09	-1.077	-1.077
CAST	-0.737	-0.737
CCcont	-0.886	-0.886
DS01	-0.089	-0.089
DS02	0.452	0.452
DS04	-0.141	-0.141
DS0c	-0.11	-0.11
GP01	-0.144	-0.144
GP02	0.179	0.179
GP0c	-0.346	-0.346
NOD	0.028	0.028
NZO	-0.551	-0.551
PWK	-0.033	-0.033
H37Rv_KO_CtpC	0.141	0.141
H37Rv_KO_CtpD	0.021	0.021
H37Rv_KO_Rv1272	-0.146	-0.146
H37Rv_KO_SugABC	0.372	0.372
H37Rv_KO_MbtN	-0.066	-0.066
Trans05	-0.775	-0.775
macrophage_unactivated	-0.458	-0.458
IL1	-0.454	-0.454
Rapamycin	-0.746	-0.746
Tcell	-0.896	-0.896
GMCSF	-0.288	-0.288
IFNab	-0.596	-0.596
IFNg	-0.313	-0.313
IFNg_GMCSF1	-0.126	-0.126
Rv1432_day32	0.227	0.227
Rv1565c_day32	0.362	0.362
secA2_input	0.307	0.307
delta_Rv3594	0.24	0.24
delta_Rv3717	-0.154	-0.154
delta_Rv3811	-0.547	-0.547
delta_Rv0954	-0.217	-0.217
PonA1	0.292	0.292
EccD1_KO	-0.533	-0.533
EspI_KO	-0.302	-0.302
PE35_KO	0.128	0.128
PPE68_KO	-0.019	-0.019
glycerol2	-0.523	-0.523
lignocerate	-0.318	-0.318
oleate	-0.699	-0.699
phosphatidylcholine	-0.237	-0.237
acetate	-0.454	-0.454
glucAc	-0.32	-0.32
Rv0950ko	0.06	0.06
Rv1096ko	-0.57	-0.57
Rv3684ko	-0.717	-0.717
delta_otsA_trehalose	0.592	0.592